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Review
. 2024 Oct 9;13(19):6007.
doi: 10.3390/jcm13196007.

Arterial Thrombosis in Acute Respiratory Infections: An Underestimated but Clinically Relevant Problem

Anastasiya S Babkina  1 , Mikhail V Pisarev  1 , Andrey V Grechko  1 , Arkady M Golubev  1
Affiliations
Review

Arterial Thrombosis in Acute Respiratory Infections: An Underestimated but Clinically Relevant Problem

Anastasiya S Babkina et al. J Clin Med. .

Abstract

During the COVID-19 pandemic, there was increased interest in the issue of thrombotic complications of acute respiratory infections. Clinical reports and pathological studies have revealed that thrombus formation in COVID-19 may involve the venous and arterial vasculature. As thrombotic complications of infectious respiratory diseases are increasingly considered in the context of COVID-19, the fact that thrombosis in lung diseases of viral and bacterial etiology was described long before the pandemic is overlooked. Pre-pandemic studies show that bacterial and viral respiratory infections are associated with an increased risk of thrombotic complications such as myocardial infarction, ischemic stroke, pulmonary embolism, and other critical illnesses caused by arterial and venous thrombosis. This narrative review article aims to summarize the current evidence regarding thrombotic complications and their pathogenesis in acute lower respiratory tract infections.

Keywords: ARDS; COVID-19; arterial thrombosis; pneumonia; respiratory infections.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Key components of the pathogenesis of arterial thrombosis in acute respiratory infections.
Figure 2
Figure 2
In situ pulmonary artery thrombosis (PAT) in the pathogenesis of acute lower respiratory tract infections.
Figure 3
Figure 3
Issues that need to be resolved to improve methods of prevention, diagnosis, and treatment of thrombotic complications of acute lower respiratory tract infections.
See this image and copyright information in PMC

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