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. 2024 Sep 25;12(19):1917.
doi: 10.3390/healthcare12191917.

Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors

Alba Marcos-Delgado  1   2   3 , Vicente Martín-Sánchez  1   2   3 , Ana Molina-Barceló  4 , Jessica Alonso-Molero  3   5 , Beatriz Pérez-Gómez  3   6 , Marina Pollán  3   6 , Nuria Aragonés  3   7 , María Ederra-Sanza  3   8   9 , Guillermo Fernández-Tardón  3   10 , Gemma Binefa  3   11   12 , Victor Moreno  3   11   12 , Rocío Barrios-Rodríguez  3   13   14 , Pilar Amiano  3   15 , José María Huerta  3   16 , Enrique Pastor Teso  17 , Juan Alguacil  3   18 , Gemma Castaño-Vinyals  3   19   20   21 , Manolis Kogevinas  3   19   20   21 , Antonio José Molina de la Torre  1   2   3
Affiliations

Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors

Alba Marcos-Delgado et al. Healthcare (Basel). .

Abstract

The aim of our study is to evaluate the relationship between sociodemographic and clinical characteristics of individuals with Colorectal Cancer (CRC), tumour-intrinsic characteristics and treatment received with health-related quality of life (HRQoL).

Methods: Cross-sectional analysis of data from 805 survivors from the MCC study was conducted. HRQoL was assessed through a general and specific questionnaire, SF-12 and FCSI (Colorectal Symptom Index). Statistical analyses were performed with linear regression with adjustment for sociodemographic variables, stage at diagnosis and histological grade.

Results: Participants had survived a median of 7.9 years from diagnosis (IQR 7.1-8.5 years). Age at diagnosis, sex and area showed a clear association with HRQoL in both physical and mental dimensions of the SF-12 questionnaire. A direct association between CRC recurrence was also found in the PCS-12 and MCS-12 dimensions and radical surgery in the PCS-12. Regarding the scores in FCSI questionnaire, statistically significant differences were observed by sex, age and area, with older women being the most impaired (p < 0.001).

Conclusions: Age, sex and area was associated with lower scores of HRQoL among CRC survivors. Knowing the determinants related to HRQoL would allow us to lay the groundwork to develop strategies that help reduce morbidity and mortality, relapses and increase HRQoL.

Keywords: cancer survivors; colorectal cancer; health-related quality of life (HRQoL).

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of the followed cases of Colorectal Cancer in MCC study.
Figure 2
Figure 2
Marginal means for aggregated physical/mental dimensions of health-related quality of life and functional colorectal symptom index by baseline categories of age at diagnosis, stratified by sex.
See this image and copyright information in PMC

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