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Review
. 2024 Oct 1;25(19):10604.
doi: 10.3390/ijms251910604.

Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer

Pratibha Pandey  1   2 , Seema Ramniwas  3 , Shivam Pandey  4 , Sorabh Lakhanpal  5 , G Padmapriya  6 , Shivang Mishra  7 , Mandeep Kaur  8 , Ayash Ashraf  9 , M Ravi Kumar  10 , Fahad Khan  11
Affiliations
Review

Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer

Pratibha Pandey et al. Int J Mol Sci. .

Abstract

Copper is a vital trace element in oxidized and reduced forms. It plays crucial roles in numerous biological events such as redox chemistry, enzymatic reactions, mitochondrial respiration, iron metabolism, autophagy, and immune modulation. Maintaining the balance of copper in the body is essential because its deficiency and excess can be harmful. Abnormal copper metabolism has a two-fold impact on the development of tumors and cancer treatment. Cuproptosis is a form of cell death that occurs when there is excessive copper in the body, leading to proteotoxic stress and the activation of a specific pathway in the mitochondria. Research has been conducted on the advantageous role of copper ionophores and chelators in cancer management. This review presents recent progress in understanding copper metabolism, cuproptosis, and the molecular mechanisms involved in using copper for targeted therapy in cervical cancer. Integrating trace metals and minerals into nanoparticulate systems is a promising approach for controlling invasive tumors. Therefore, we have also included a concise overview of copper nanoformulations targeting cervical cancer cells. This review offers comprehensive insights into the correlation between cuproptosis-related genes and immune infiltration, as well as the prognosis of cervical cancer. These findings can be valuable for developing advanced clinical tools to enhance the detection and treatment of cervical cancer.

Keywords: cervical cancer; copper; cuproptosis; immunotherapy; long coding RNAs; metabolism.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Copper metabolism is regulated at both organ and cellular levels. Copper ion uptake is mediated by SLC31A2 and SLC31A1, and copper export is driven by ATP7B and ATP7A. In cells, copper is transported to different organelles (for bioavailability) via numerous copper-binding proteins (COX17, CCS, and ATOX1). The binding of MT2, GSH, and MT2 to copper can prevent the cytotoxicity of excess copper.
Figure 2
Figure 2
Copper induces cell death in cancer therapeutics. Increased copper concentration in cancer cells increases ETC, DNA replication, glutamine transporters, harmful cuproptosis mediators, and reduced levels of positive cuproptosis mediators and antioxidant enzymes. These alterations result in cell death.
Figure 3
Figure 3
Cuproptosis-related lncRNAs’ role in cervical cancer.
See this image and copyright information in PMC

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