Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 15;16(9):e69465.
doi: 10.7759/cureus.69465. eCollection 2024 Sep.

Clinical Outcomes of Sickle Cell Disease Patients With Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Nationwide Analysis

Oluwasegun M Akinti  1 , Jamal C Perry  2 , Temi Ediale  1 , Muzammil Rehman  1 , Henry O Aiwuyo  1
Affiliations

Clinical Outcomes of Sickle Cell Disease Patients With Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Nationwide Analysis

Oluwasegun M Akinti et al. Cureus. .

Abstract

Sickle cell disease (SCD) patients are predisposed to various cardiovascular complications due to the nature and progression of the disease; the clinical outcomes of SCD patients experiencing myocardial infarction (MI) and undergoing percutaneous coronary intervention (PCI) are not well known. This study aims to explore a comprehensive nationwide analysis of the clinical outcomes in SCD patients who have suffered an MI and subsequently undergone PCI. It also identifies potential complications and compares their outcomes with non-SCD counterparts with the same interventions. We conducted a retrospective analysis of SCD patients who have suffered an MI and subsequently undergone PCI using the National Inpatient Sample (NIS) database from 2016 to 2020. The primary outcome was mortality, while the secondary outcomes were the average length of stay, comorbid conditions, and cardiovascular outcomes. Logistic, linear, and Poisson regression model analysis applied for outcomes and adjusting co-founders. P-value <0.05 was considered significant. A total of 775 patients were analyzed for MI who had PCI with SCD, with a mean age of 58±1.06 years. SCD patients exhibited higher rates of comorbidities, including diabetes mellitus (45.81% vs. 37.84%), obesity (23.87% vs. 20.85%), and chronic kidney disease (CKD) (29.03% vs. 17.36%). Heart failure was more common among SCD patients with 34.19% vs. 26.02% in non-SCD patients (OR 1.5, CI 1.1-2.1, p-value=0.02). Other cardiovascular complications such as stroke, ventricular arrhythmias, atrial fibrillation, pulmonary edema, cardiogenic shock, cardiac arrest, and mortality did not significantly differ between SCD and non-SCD (P-values >0.05). The study observed that SCD patients experienced a significantly higher incidence of heart failure than non-SCD patients. This implies that SCD patients undergoing PCI for MI exhibit distinct clinical outcomes compared to their non-SCD counterparts.

Keywords: clinical outcomes; heart failure; myocardial infarction; national inpatient sample; nationwide analysis; percutaneous coronary intervention; sickle cell disease.

PubMed Disclaimer

Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Differences in clinical outcomes between SCD and non-SCD patients
IABP, intra-aortic balloon pump; SCD, sickle cell disease
See this image and copyright information in PMC

References

    1. Cappelli B, Gluckman E, Ghanem K, et al. Springer; 2019. The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies. - PubMed
    1. Cardiovascular manifestations of sickle cell disease. Hammoudi N, Lionnet F, Redheuil A, Montalescot G. Eur Heart J. 2020;41:1365–1373. - PubMed
    1. Cardiovascular complications of sickle cell disease. Sachdev V, Rosing DR, Thein SL. Trends Cardiovasc Med. 2021;31:187–193. - PMC - PubMed
    1. Management of acute coronary syndrome in the older adult population: a scientific statement from the American Heart Association. Damluji AA, Forman DE, Wang TY, et al. Circulation. 2023;147:0–62. - PMC - PubMed
    1. Agency for Healthcare Research and Quality, Rockville. HCUP Databases. Healthcare Cost and Utilization Project (HCUP) [ May; 2024 ]. 2024. https://www.ahrq.gov/data/hcup/index.html https://www.ahrq.gov/data/hcup/index.html - PubMed

LinkOut - more resources