Parsing Signal vs Noise-Secondary Analyses of RCTs

Gregg C Fonarow^{1

2}, Ajay J Kirtane^{3

4}, Clyde W Yancy^{5

6}

Affiliations

¹ Ahmanson-UCLA Cardiomyopathy Center, David Geffen School of Medicine, University of California, Los Angeles.
² Section Editor, JAMA Cardiology.
³ Division of Cardiology, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York.
⁴ Associate Editor, JAMA Cardiology.
⁵ Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁶ Deputy Editor, JAMA Cardiology.

Comment

Gregg C Fonarow et al. JAMA Cardiol. 2025.

. 2025 Jan 1;10(1):31.

doi: 10.1001/jamacardio.2024.3329.

Gregg C Fonarow^{1

2}, Ajay J Kirtane^{3

4}, Clyde W Yancy^{5

6}

¹ Ahmanson-UCLA Cardiomyopathy Center, David Geffen School of Medicine, University of California, Los Angeles.
² Section Editor, JAMA Cardiology.
³ Division of Cardiology, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York.
⁴ Associate Editor, JAMA Cardiology.
⁵ Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁶ Deputy Editor, JAMA Cardiology.

No abstract available

Comment on

Coronary Revascularization Guided With Fractional Flow Reserve or Instantaneous Wave-Free Ratio: A 5-Year Follow-Up of the DEFINE FLAIR Randomized Clinical Trial.
Escaned J, Travieso A, Dehbi HM, Nijjer SS, Sen S, Petraco R, Patel M, Serruys PW, Davies J; DEFINE FLAIR Investigators. Escaned J, et al. JAMA Cardiol. 2025 Jan 1;10(1):25-31. doi: 10.1001/jamacardio.2024.3314. JAMA Cardiol. 2025. PMID: 39412778 Clinical Trial.