Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct;40(9):2112-2117.
doi: 10.12669/pjms.40.9.8728.

LDH and NLR, as inflammatory markers, the independent risk factors for COVID-19 complicated with respiratory failure in elderly patients

Shan Wang  1 , Jia Liu  2 , Song Hu  3 , Yongjun Mao  4
Affiliations

LDH and NLR, as inflammatory markers, the independent risk factors for COVID-19 complicated with respiratory failure in elderly patients

Shan Wang et al. Pak J Med Sci. 2024 Oct.

Abstract

Objective: Lactate dehydrogenase (LDH) is an enzyme that is responsible for the production of lactic acid, which is a necessary byproduct when the body does not have enough oxygen. LDH levels in the blood can be used as a marker to predict mortality in patients with ARDS, severe COVID-19, and cancer. To analyze the clinical characteristics of COVID-19 in the elderly and the correlation between LDH and respiratory failure in COVID-19 patients, to improve the identification and management of this type of pneumonia by clinicians.

Methods: This was a single-center retrospective study. We performed routine laboratory tests in 105 COVID-19 patients admitted to the affiliated hospital of Qingdao University (Qingdao, China) from October 1, 2022 to February 1, 2023. The diagnosis of respiratory failure was established based on the results of blood gas analysis upon admission.

Results: The median age was 79 years. Among all univariable parameters, LDH, neutrophil to lymphocyte ratio (NLR) and Prothrombin Time (PT) were significantly independent risk factors of RF in elderly COVID-19 patients. LDH (AUC=0.829) also had a maximum specificity (96.5%), with the cutoff value of 280.5.

Conclusion: The levels of LDH, NLR, and PT may serve as potential indicators for elderly COVID-19 patients combined with respiratory failure. LDH, NLR and PT assays can be beneficial for patients who need closer respiratory monitoring and more aggressive supportive care to prevent a negative prognosis.

Keywords: COVID-19; LDH; Respiratory failure; Senior.

PubMed Disclaimer

Conflict of interest statement

Conflict Interest: None.

Figures

Fig.1
Fig.1
Receiver operating characteristic (ROC) curves for LDH, NLR and PT in patients with respiratory failure.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-5. - PMC - PubMed
    1. Poggiali E, Zaino D, Immovilli P, Rovero L, Losi G, Dacrema A, et al. Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients. Clin Chim Acta. 2020;509:135–138. doi:10.1016/j.cca.2020.06.012. - PMC - PubMed
    1. Poggiali E, Dacrema A, Bastoni D, Tinelli V, Demichele E, Mateo Ramos P, et al. Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? Radiology. 2020;295(3):E6. doi:10.1148/radiol.2020200847. - PMC - PubMed
    1. Poggiali E, Mateo Ramos P, Bastoni D, Vercelli A, Magnacavallo A. Abdominal Pain:A Real Challenge in Novel COVID-19 Infection. Eur J Case Rep Intern Med. 2020;7(4):001632. doi:10.12890/2020_001632. - PMC - PubMed
    1. Vo P, Kharasch VS. Respiratory failure. Pediatr Rev. 2014;35(11):476–484. quiz 485-486. doi:10.1542/pir.35-11-476. - PubMed

LinkOut - more resources