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Review
. 2024 Oct 15:17:11786388241263680.
doi: 10.1177/11786388241263680. eCollection 2024.

Therapeutic Effects of Vitamins and Nutritional Supplements on Sinusitis: A Narrative Review

Mohadeseh Poudineh  1 , Farhad Nikzad  2   3 , Sadaf Parvin  4 , Mohammad Ghaheri  5 , Shahin Sabbaghi  4 , Erfan Kazemi  6 , Mohammad Mahdi Ghodrati  4 , Fatemeh Mohammadyari  7 , Sara Saeedpour  4 , Shekoufeh Mohammadpour  8 , Narjes Sadat Farizani Gohari  9 , Farbod Heydarasadi  3   4 , Dorsa Abolhasani  7 , Sepehr Olangian-Tehrani  3   4 , Armin Alinezhad  10
Affiliations
Review

Therapeutic Effects of Vitamins and Nutritional Supplements on Sinusitis: A Narrative Review

Mohadeseh Poudineh et al. Nutr Metab Insights. .

Abstract

Sinusitis, one of the most prevalent and undertreated disorders, is a term used to describe inflammation of the paranasal sinuses caused by either infectious or non-infectious sources. Bacterial, viral, or fungal infections can all cause sinusitis. Sinusitis is classified into 3 types: acute, subacute, and chronic. Acute sinusitis lasts for less than 1 month, subacute sinusitis lasts from 1 to 3 months, and chronic sinusitis persists for over 3 months. This condition affects a significant portion of the population, imposing a substantial burden on the healthcare system. Antibiotics are the gold standard of bacterial sinusitis treatment. However, due to the rise of antimicrobial resistance, especially in immune-compromised patients, it is necessary to investigate potential adjunctive therapies. Based on the literature, vitamins (eg, vitamin D) have antioxidant, anti-inflammatory, and immune-modulatory properties and may effectively treat sinusitis and reduce mucous membrane inflammation. Besides vitamins, many other supplements like quercetin, sinupret, and echinacea have immunomodulatory effects and have shown promising results in sinusitis treatment. In this review, we look at the therapeutic role, safety, and efficacy of vitamins and nutritional supplements in sinusitis treatment.

Keywords: Sinusitis; nutritional supplements; sinupret; upper respiratory tract; vitamins; zinc supplements.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
A review of therapeutic effects of vitamins and various nutrition on sinusitis. Vitamins and nutritional supplements can reduce sinusitis symptoms.
See this image and copyright information in PMC

References

    1. Stokes PJ, Rimmer J. The relationship between serum vitamin D and chronic rhinosinusitis: a systematic review. Am J Rhinol Allergy. 2016;30:23-28. - PubMed
    1. Battisti AS, Modi P, Pangia J. Sinusitis. StatPearls Publishing LLC; 2021. - PubMed
    1. Xu Y, Quan H, Faris P, et al. Prevalence and incidence of diagnosed chronic rhinosinusitis in Alberta, Canada. Otolaryngol Head Neck Surg. 2016;142:1063-1069. - PubMed
    1. Philpott CM, Erskine S, Hopkins C, et al. Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respir Res. 2018;19:129. - PMC - PubMed
    1. Schilling AL, Carcella AR, Moore J, et al. Compatibility of a thermoresponsive and controlled release system for promoting sinonasal cilia regeneration. Macromol Biosci. 2021;21:2100277. - PubMed