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Clinical Trial
. 1986 Jan;36(1):98-100.
doi: 10.1212/wnl.36.1.98.

Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia

F Carella, F Girotti, G Scigliano, T Caraceni, A M Joder-Ohlenbusch, P J Schechter
Clinical Trial

Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia

F Carella et al. Neurology. 1986 Jan.

Abstract

Six patients with different forms of dystonia were treated with gamma-vinyl GABA, a specific enzyme-activated inhibitor of GABA-transaminase, in a double-blind, placebo-controlled crossover study. gamma-Vinyl GABA therapy, 2 g daily for 2 weeks, was compared with placebo by weekly assessments. There were no consistent changes in three evaluation scores. Agents that augment CNS GABA are unlikely to benefit patients with generalized dystonia.

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