Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu^{1

2}, Qiang Fu^{3

4

5}, Dominika Wilczok^{6

7}, Kejun Ying⁸, Aaron King⁹, Adam Antebi^{2

10}, Aleksandar Vojta¹¹, Alexandra Stolzing¹², Alexey Moskalev¹³, Anastasia Georgievskaya¹⁴, Andrea B Maier¹⁵, Andrea Olsen¹⁶, Anja Groth¹⁷, Anna Katharina Simon^{18

19}, Anne Brunet²⁰, Aisyah Jamil²¹, Anton Kulaga^{22

23}, Asif Bhatti²⁴, Benjamin Yaden²⁵, Bente Klarlund Pedersen²⁶, Björn Schumacher²⁷, Boris Djordjevic^{28

29}, Brian Kennedy¹⁵, Chieh Chen^{30

31}, Christine Yuan Huang³², Christoph U Correll^{33

34}, Coleen T Murphy^{35

36}, Collin Y Ewald³⁷, Danica Chen^{38

39

40}, Dario Riccardo Valenzano⁴¹, Dariusz Sołdacki⁴², David Erritzoe⁴³, David Meyer²⁷, David A Sinclair⁴⁴, Eduardo Nunes Chini⁴⁵, Emma C Teeling⁴⁶, Eric Morgen⁴⁷, Eric Verdin⁴⁸, Erik Vernet⁴⁹, Estefano Pinilla⁵⁰, Evandro F Fang⁵¹, Evelyne Bischof⁵², Evi M Mercken⁵³, Fabian Finger⁵⁴, Folkert Kuipers⁵⁵, Frank W Pun⁵⁶, Gabor Gyülveszi⁵⁷, Gabriele Civiletto⁵⁸, Garri Zmudze⁵⁹, Gil Blander⁶⁰, Harold A Pincus⁶¹, Joshua McClure⁶², James L Kirkland⁶³, James Peyer⁶⁴, Jamie N Justice⁶⁵, Jan Vijg⁶⁶, Jennifer R Gruhn⁶⁷, Jerry McLaughlin⁶⁸, Joan Mannick⁶⁹, João Passos⁷⁰, Joseph A Baur⁷¹, Joe Betts-LaCroix⁷², John M Sedivy⁷³, John R Speakman⁷⁴, Jordan Shlain⁷⁵, Julia von Maltzahn⁷⁶, Katrin I Andreasson⁷⁷, Kelsey Moody⁷⁸, Konstantinos Palikaras⁷⁹, Kristen Fortney⁴⁷, Laura J Niedernhofer⁸⁰, Lene Juel Rasmussen⁸¹, Liesbeth M Veenhoff⁵⁵, Lisa Melton⁸², Luigi Ferrucci⁸³, Marco Quarta^{84

85

86}, Maria Koval⁸⁷, Maria Marinova⁸⁸, Mark Hamalainen⁸⁹, Maximilian Unfried^{15

90}, Michael S Ringel⁹¹, Milos Filipovic⁹², Mourad Topors⁹³, Natalia Mitin⁹⁴, Nawal Roy⁹⁵, Nika Pintar⁹⁶, Nir Barzilai⁹⁷, Paolo Binetti⁵⁰, Parminder Singh⁴⁸, Paul Kohlhaas⁹⁸, Paul D Robbins⁹⁹, Paul Rubin⁴⁷, Peter O Fedichev¹⁰⁰, Petrina Kamya¹⁰¹, Pura Muñoz-Canoves¹⁰², Rafael de Cabo¹⁰³, Richard G A Faragher¹⁰⁴, Rob Konrad¹⁰⁵, Roberto Ripa², Robin Mansukhani¹⁰⁶, Sabrina Büttner¹⁰⁷, Sara A Wickström¹⁰⁸, Sebastian Brunemeier¹⁰⁹, Sergey Jakimov⁵⁹, Shan Luo¹¹⁰, Sharon Rosenzweig-Lipson⁶⁸, Shih-Yin Tsai¹¹¹, Stefanie Dimmeler¹¹², Thomas A Rando¹¹³, Tim R Peterson¹¹⁴, Tina Woods^{115

116}, Tony Wyss-Coray⁷⁷, Toren Finkel¹¹⁷, Tzipora Strauss^{118

119}, Vadim N Gladyshev⁸, Valter D Longo¹²⁰, Varun B Dwaraka¹²¹, Vera Gorbunova¹²², Victoria A Acosta-Rodríguez¹²³, Vincenzo Sorrentino¹⁵, Vittorio Sebastiano¹²⁴, Wenbin Li¹²⁵, Yousin Suh¹²⁶, Alex Zhavoronkov²¹, Morten Scheibye-Knudsen⁸¹, Daniela Bakula⁸¹

Affiliations

¹ Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
² Max Planck Institute for Biology of Ageing, Cologne, Germany.
³ Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China.
⁴ Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China.
⁵ Shandong Cellogene Pharmaceutics Co. LTD, Yantai, China.
⁶ Duke Kunshan University, Kunshan, Jiangsu, China.
⁷ Duke University, Durham, NC, USA.
⁸ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA.
⁹ Foresight Institute, San Francisco, CA 91125, USA.
¹⁰ Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
¹¹ Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
¹² Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
¹³ Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.
¹⁴ HautAI OÜ, Tallinn, Estonia.
¹⁵ Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
¹⁶ California Institute of Technology, Pasadena, CA 91125, USA.
¹⁷ Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
¹⁸ Max Delbrück Center for Molecular Medicine, Berlin, Germany.
¹⁹ The Kennedy Institute of Rheumatology, Oxford, UK.
²⁰ Department of Genetics, Stanford University, Stanford, CA 94305, USA.
²¹ Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.
²² Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
²³ Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.
²⁴ America's Frontier Fund, VA 23320, USA.
²⁵ Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA.
²⁶ Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark.
²⁷ Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.
²⁸ 199 Biotechnologies Ltd., London, UK.
²⁹ University College London, London, UK.
³⁰ Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA.
³¹ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
³² Hong Kong Quantum AI Lab, Hong Kong.
³³ Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA.
³⁴ Charité - University Medicine, Berlin, Germany.
³⁵ Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
³⁶ Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
³⁷ Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland.
³⁸ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
³⁹ Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
⁴⁰ Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
⁴¹ Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany.
⁴² Longevity Center Europe, Warsaw, Poland.
⁴³ Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK.
⁴⁴ Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA.
⁴⁵ Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA.
⁴⁶ School of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland.
⁴⁷ BioAge Labs, Richmond, CA 94530, USA.
⁴⁸ Buck Institute for Research on Aging, Novato, CA 94945, USA.
⁴⁹ Research and Early Development, Maaleov 2760, Denmark.
⁵⁰ VitaDAO, Ottawa, ON K1V 9K6, Canada.
⁵¹ Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
⁵² Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵³ Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.
⁵⁴ Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark.
⁵⁵ European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁵⁶ Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China.
⁵⁷ Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland.
⁵⁸ Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland.
⁵⁹ LongeVC, Riga, Latvia.
⁶⁰ InsideTracker, Cambridge, MA 02114, USA.
⁶¹ Department of Psychiatry, Columbia University, New York, NY 10012, USA.
⁶² Maxwell Biosciences, Austin, TX 73301, USA.
⁶³ Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
⁶⁴ Cambrian Bio, Inc., New York, NY 10012, USA.
⁶⁵ XPRIZE Foundation, Culver City, CA 90230, USA.
⁶⁶ Department of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA.
⁶⁷ Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁶⁸ Life Biosciences, Boston, MA 02116, USA.
⁶⁹ Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA.
⁷⁰ Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
⁷¹ Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA.
⁷² Retro Biosciences, Inc., Redwood City, CA 94061, USA.
⁷³ Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA.
⁷⁴ Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁷⁵ Private Medical, San Francisco, CA 94107, USA.
⁷⁶ Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany.
⁷⁷ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷⁸ Ichor Life Sciences, Inc., LaFayette, NY 13084, USA.
⁷⁹ Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁸⁰ Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA.
⁸¹ Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
⁸² Nature Biotechnology, Springer Nature, London, UK.
⁸³ Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA.
⁸⁴ Rubedo Life Sciences, Sunnyvale, CA 94043, USA.
⁸⁵ Turn Biotechnologies, Mountain View 94039, CA, USA.
⁸⁶ Phaedon Institute, Oakland, CA 94501, USA.
⁸⁷ Institute of Biochemistry of the Romanian Academy, Romania.
⁸⁸ Fertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
⁸⁹ Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA.
⁹⁰ Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore.
⁹¹ Boston Consulting Group, Boston, MA 02210, USA.
⁹² Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany.
⁹³ Repair Biotechnologies, Inc., Syracuse, NY 13210, USA.
⁹⁴ Sapere Bio, Triangle Research Park, NC 27213, USA.
⁹⁵ Holmusk, New York, NY 10012, USA.
⁹⁶ AniBiome, Zagreb, Croatia.
⁹⁷ Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA.
⁹⁸ Molecule, Neuhausen am Rheinfall, Switzerland.
⁹⁹ Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA.
¹⁰⁰ Gero PTE, Singapore, Singapore.
¹⁰¹ Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada.
¹⁰² Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA.
¹⁰³ Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA.
¹⁰⁴ Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK.
¹⁰⁵ Biolytica, Zug, Switzerland.
¹⁰⁶ Deciduous Therapeutics, San Francisco, CA 94107, USA.
¹⁰⁷ Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden.
¹⁰⁸ Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
¹⁰⁹ Healthspan Capital, El Cerrito, CA 94530, USA.
¹¹⁰ School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
¹¹¹ Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
¹¹² Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany.
¹¹³ Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
¹¹⁴ Bioio, Inc., St. Louis, MO 63110, USA.
¹¹⁵ Collider Heath, London, UK.
¹¹⁶ Healthy Longevity Champion, National Innovation Centre for Ageing, UK.
¹¹⁷ Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA.
¹¹⁸ Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel.
¹¹⁹ Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
¹²⁰ Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA.
¹²¹ TruDiagnostic, Lexington, KY 40503, USA.
¹²² Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.
¹²³ Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
¹²⁴ Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA.
¹²⁵ Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
¹²⁶ Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA.

PMID: 39418098
PMCID: PMC11552646
DOI: 10.18632/aging.206135

Review

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu et al. Aging (Albany NY). 2024.

. 2024 Oct 16;16(20):12955-12976.

doi: 10.18632/aging.206135. Epub 2024 Oct 16.

Authors

Affiliations

¹ Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
² Max Planck Institute for Biology of Ageing, Cologne, Germany.
³ Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China.
⁴ Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China.
⁵ Shandong Cellogene Pharmaceutics Co. LTD, Yantai, China.
⁶ Duke Kunshan University, Kunshan, Jiangsu, China.
⁷ Duke University, Durham, NC, USA.
⁸ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA.
⁹ Foresight Institute, San Francisco, CA 91125, USA.
¹⁰ Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
¹¹ Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
¹² Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
¹³ Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.
¹⁴ HautAI OÜ, Tallinn, Estonia.
¹⁵ Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
¹⁶ California Institute of Technology, Pasadena, CA 91125, USA.
¹⁷ Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
¹⁸ Max Delbrück Center for Molecular Medicine, Berlin, Germany.
¹⁹ The Kennedy Institute of Rheumatology, Oxford, UK.
²⁰ Department of Genetics, Stanford University, Stanford, CA 94305, USA.
²¹ Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.
²² Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
²³ Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.
²⁴ America's Frontier Fund, VA 23320, USA.
²⁵ Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA.
²⁶ Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark.
²⁷ Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.
²⁸ 199 Biotechnologies Ltd., London, UK.
²⁹ University College London, London, UK.
³⁰ Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA.
³¹ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
³² Hong Kong Quantum AI Lab, Hong Kong.
³³ Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA.
³⁴ Charité - University Medicine, Berlin, Germany.
³⁵ Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
³⁶ Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
³⁷ Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland.
³⁸ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
³⁹ Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
⁴⁰ Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
⁴¹ Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany.
⁴² Longevity Center Europe, Warsaw, Poland.
⁴³ Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK.
⁴⁴ Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA.
⁴⁵ Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA.
⁴⁶ School of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland.
⁴⁷ BioAge Labs, Richmond, CA 94530, USA.
⁴⁸ Buck Institute for Research on Aging, Novato, CA 94945, USA.
⁴⁹ Research and Early Development, Maaleov 2760, Denmark.
⁵⁰ VitaDAO, Ottawa, ON K1V 9K6, Canada.
⁵¹ Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
⁵² Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵³ Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.
⁵⁴ Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark.
⁵⁵ European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁵⁶ Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China.
⁵⁷ Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland.
⁵⁸ Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland.
⁵⁹ LongeVC, Riga, Latvia.
⁶⁰ InsideTracker, Cambridge, MA 02114, USA.
⁶¹ Department of Psychiatry, Columbia University, New York, NY 10012, USA.
⁶² Maxwell Biosciences, Austin, TX 73301, USA.
⁶³ Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
⁶⁴ Cambrian Bio, Inc., New York, NY 10012, USA.
⁶⁵ XPRIZE Foundation, Culver City, CA 90230, USA.
⁶⁶ Department of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA.
⁶⁷ Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁶⁸ Life Biosciences, Boston, MA 02116, USA.
⁶⁹ Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA.
⁷⁰ Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
⁷¹ Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA.
⁷² Retro Biosciences, Inc., Redwood City, CA 94061, USA.
⁷³ Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA.
⁷⁴ Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁷⁵ Private Medical, San Francisco, CA 94107, USA.
⁷⁶ Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany.
⁷⁷ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷⁸ Ichor Life Sciences, Inc., LaFayette, NY 13084, USA.
⁷⁹ Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁸⁰ Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA.
⁸¹ Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
⁸² Nature Biotechnology, Springer Nature, London, UK.
⁸³ Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA.
⁸⁴ Rubedo Life Sciences, Sunnyvale, CA 94043, USA.
⁸⁵ Turn Biotechnologies, Mountain View 94039, CA, USA.
⁸⁶ Phaedon Institute, Oakland, CA 94501, USA.
⁸⁷ Institute of Biochemistry of the Romanian Academy, Romania.
⁸⁸ Fertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
⁸⁹ Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA.
⁹⁰ Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore.
⁹¹ Boston Consulting Group, Boston, MA 02210, USA.
⁹² Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany.
⁹³ Repair Biotechnologies, Inc., Syracuse, NY 13210, USA.
⁹⁴ Sapere Bio, Triangle Research Park, NC 27213, USA.
⁹⁵ Holmusk, New York, NY 10012, USA.
⁹⁶ AniBiome, Zagreb, Croatia.
⁹⁷ Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA.
⁹⁸ Molecule, Neuhausen am Rheinfall, Switzerland.
⁹⁹ Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA.
¹⁰⁰ Gero PTE, Singapore, Singapore.
¹⁰¹ Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada.
¹⁰² Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA.
¹⁰³ Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA.
¹⁰⁴ Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK.
¹⁰⁵ Biolytica, Zug, Switzerland.
¹⁰⁶ Deciduous Therapeutics, San Francisco, CA 94107, USA.
¹⁰⁷ Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden.
¹⁰⁸ Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
¹⁰⁹ Healthspan Capital, El Cerrito, CA 94530, USA.
¹¹⁰ School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
¹¹¹ Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
¹¹² Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany.
¹¹³ Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
¹¹⁴ Bioio, Inc., St. Louis, MO 63110, USA.
¹¹⁵ Collider Heath, London, UK.
¹¹⁶ Healthy Longevity Champion, National Innovation Centre for Ageing, UK.
¹¹⁷ Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA.
¹¹⁸ Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel.
¹¹⁹ Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
¹²⁰ Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA.
¹²¹ TruDiagnostic, Lexington, KY 40503, USA.
¹²² Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.
¹²³ Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
¹²⁴ Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA.
¹²⁵ Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
¹²⁶ Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA.

PMID: 39418098
PMCID: PMC11552646
DOI: 10.18632/aging.206135

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Keywords: artificial intelligence; biotechnology; healthy longevity.

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Conflict of interest statement

CONFLICTS OF INTEREST: A.G. is affiliated with Haut.AI. A.K.S. is consulting for The Longevity Lab and Primeadine. D.S. is an employee of the Longevity Center Group. J.L.K. has a financial interest related to this research, including patents and pending patents covering senolytic drugs and their uses that are held by Mayo Clinic. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic conflict of interest policies. G.B. is an InsideTracker employee, and InsideTracker is the sole funder of Dr. Blander. G.C is the employee of DSM-Firmenich (Kaiseraugst, Switzerland). J.H. is a founder and scientific advisory board member of LongLifeRx and Aiance. J.S. is affiliated with Private Medical. J.V. is a co-founder of Singulomics Inc. and Mutagentech Inc. K.J.M. holds equity in Lysoclear, Inc. which is commercializing the presented technology. K.P. is funded by the Fondation Santé (19656) and the European Union (European Research Council; ERC), under grant agreement “ERC-GA101077374-SynaptoMitophagy”. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. M.H. is affiliated with Synthego, Frontier Bio, Ligandal, Longshot Space. M.S-K. is supported by the Novo Nordisk Foundation Challenge Programme (NNF17OC0027812), the Nordea Foundation (02-2017-1749), the Neye Foundation, the Lundbeck Foundation (R324-2019-1492), the Ministry of Higher Education and Science (0238-00003B), VitaDAO and Insilico Medicine. M.Q. is founder and shareholder of Rubedo Life Sciences and Turn Biotechnologies. P.K., F.W.P., A.J. and A.Z. are employed at Insilico Medicine. P.M. was employed at Pompeu Fabra University and currently is employed at Altos Labs. T.F. co-founder and equity holder Generian Pharmaceuticals and Coloma Therapeutics.

Figures

**Figure 1**
**Timeline of longevity biotechnology.** Key breakthroughs the AI, Biomarkers and clocks, Geroscience, and Clinical trials and applications in ageing and longevity fields since 2013.

**Figure 2**
Framework of personalized, data-driven longevity medicine.

**Figure 3**
Integration of AI, biomarkers and clocks, geroscience, and longevity medicine in advancing human healthspan.

See this image and copyright information in PMC

References

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Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

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Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

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