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Review
. 2024 Dec:79:101625.
doi: 10.1016/j.ghir.2024.101625. Epub 2024 Oct 9.

Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease

Cheryl A Conover  1
Affiliations
Review

Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease

Cheryl A Conover. Growth Horm IGF Res. 2024 Dec.

Abstract

There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular disease. This review will describe the various roles of PAPP-A with a focus on atherosclerosis, neointimal hyperplasia, and acute coronary syndrome in animal models and in humans.

Keywords: Cardiovascular disease; Insulin-like growth factors; PAPP-A.

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Conflict of interest statement

Declaration of competing interest The author declare no competing interests.

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