LGD-4033 and a Case of Drug-Induced Liver Injury: Exploring the Clinical Implications of Off-Label Selective Androgen Receptor Modulator Use in Healthy Adults

Abstract

Selective androgen receptor modulators (SARMs), designed to treat conditions such as muscle wasting and osteoporosis, are widely used among healthy adults seeking muscle hypertrophy and enhanced athletic performance, despite a lack of Food and Drug Administration (FDA) approval. This trend may be driven by the misconception that SARMs are safer alternatives to anabolic steroids. However, SARMs such as LGD-4033 (Ligandrol) are associated with significant adverse effects, including hepatotoxicity, cardiovascular complications, endocrine disturbances, and psychiatric symptoms. This report examines the clinical implications of off-label SARM use, focusing on a case of drug-induced liver injury (DILI) in a 52-year-old male. The patient presented with pruritic jaundice, significant weight loss, and elevated liver enzymes following three months of high-dose LGD-4033 use. A diagnostic workup ruled out other potential causes of liver injury, implicating SARM use as the likely etiology. This case underscores the necessity for heightened clinical vigilance, early diagnosis, and prompt intervention to mitigate serious health outcomes associated with SARM misuse.

Keywords: drug-induced acute liver failure; drug-induced liver injury (dili); sarm; severe acute liver toxicity; supplement-related liver injury.