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Review
. 2024 Oct 3:15:1436108.
doi: 10.3389/fimmu.2024.1436108. eCollection 2024.

Towards personalized vaccines

Davide Montin  1 , Veronica Santilli  2 , Alessandra Beni  3 , Giorgio Costagliola  4 , Baldassarre Martire  5 , Maria Felicia Mastrototaro  5 , Giorgio Ottaviano  6 , Caterina Rizzo  7 , Mayla Sgrulletti  8   9 , Michele Miraglia Del Giudice  10 , Viviana Moschese  8
Affiliations
Review

Towards personalized vaccines

Davide Montin et al. Front Immunol. .

Abstract

The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored to individual genetic and immunological profiles. Integrating insights from genomics, transcriptomics, proteomics, and immunology, personalized vaccines offer the promise of enhanced efficacy and safety, revolutionizing the field of vaccinology. However, the development of personalized vaccines presents multifaceted challenges, including technical, ethical, economic, and regulatory considerations. Addressing these challenges is essential to ensure equitable access and safety of personalized vaccination strategies. Despite these hurdles, the potential of personalized vaccines to optimize responses and mitigate disease burden underscores the significance of ongoing research and collaboration in advancing precision medicine in immunization.

Keywords: genomics; precision medicine; proteomics; system vaccinology; transcriptomics; vaccines; vaccinomics and personalized vaccines.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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