Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Nov;28(11):100395.
doi: 10.1016/j.jnha.2024.100395. Epub 2024 Oct 17.

The sweet escape: Are ketones a key player in unlocking healthy aging?

Affiliations
Editorial

The sweet escape: Are ketones a key player in unlocking healthy aging?

Andreia N Cadar et al. J Nutr Health Aging. 2024 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jenna M. Bartley reports financial support was provided by UConn Health. Andreia Cadar reports financial support was provided by UConn Health. Jenna M. Bartley reports a relationship with National Institutes of Health that includes: funding grants. Andreia Cadar reports a relationship with National Institutes of Health that includes: funding grants. Corresponding author collaborates with Dr. Brianna Stubbs and Dr. John Newman — JMB. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Potential benefits of ketone bodies and ketogenic diet on common age-related concerns. Various biological processes decline with age and contribute collectively to age-related diseases and pathologies. Ketogenic diets (KD) and/or ketone bodies (ketone esters, KE) have been shown to improve different aspects of these declines. Proposed benefits to Muscle Health, Mitochondrial Function, Inflammation, Cognitive Function, Stem Cell Function, Weight/Metabolic Health, Longevity, and Malignancy are highlighted as reported from KE and KD studies in mice and humans. While more research is necessary to determine the full utility of these interventions, high potential remains for KD and KE to promote healthy aging and prevent or delay the onset of age-related declines. Created in BioRender. Bartley, J. (2024) BioRender.com/b70g258.

References

    1. Roberts M.N., Wallace M.A., Tomilov A.A., Zhou Z., Marcotte G.R., Tran D., et al. A ketogenic diet extends longevity and healthspan in adult mice. Cell Metab. 2017;26:539–546.e5. - PMC - PubMed
    1. Wallace M.A., Aguirre N.W., Marcotte G.R., Marshall A.G., Baehr L.M., Hughes D.C., et al. The ketogenic diet preserves skeletal muscle with aging in mice. Aging Cell. 2021;20:e13322. - PMC - PubMed
    1. Acuña-Catalán D., Shah S., Wehrfritz C., Nomura M., Acevedo A., Olmos C., et al. Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice. Cell Rep Med. 2024;5:101593. - PMC - PubMed
    1. Newman J.C., Covarrubias A.J., Zhao M., Yu X., Gut P., Ng C.P., et al. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab. 2017;26:547–557.e8. - PMC - PubMed
    1. Ryu S., Shchukina I., Youm Y.H., Qing H., Hilliard B., Dlugos T., et al. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. eLife. 2021;10:e66522. - PMC - PubMed

Publication types

LinkOut - more resources