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. 2024 Oct 18;14(1):24424.
doi: 10.1038/s41598-024-75506-x.

Influence of vortex vein engorgement for photodynamic therapy in central serous chorioretinopathy

Seongyong Jeong  1   2 , Wonki Kang  1   2 , Min Sagong  3   4
Affiliations

Influence of vortex vein engorgement for photodynamic therapy in central serous chorioretinopathy

Seongyong Jeong et al. Sci Rep. .

Abstract

This study evaluates the efficacy of photodynamic therapy (PDT) in treating central serous chorioretinopathy (CSC) based on the number of engorged vortex vein draining macula visualized on ultra-widefield (UWF) indocyanine green angiography (ICGA). Thirty-six eyes of 36 patients with treatment-naïve CSC were included. Macula-draining vortex veins were assessed in each quadrant using UWF ICGA. The resolution of subretinal fluid (SRF), pigment epithelial detachment (PED), ellipsoid zone (EZ) disintegrity, and retinal pigment epithelium (RPE) irregularity were evaluated at 3 months after PDT. Visual and anatomical improvements were monitored for 12 months. Logistic regression analysis was performed to identify factors associated with poor visual outcomes. A higher number of macula-draining vortex vein was associated to persistent SRF (p = 0.004), PED (p = 0.001), EZ disintegrity (p = 0.011), and RPE irregularity (p = 0.001). Macula-draining vortex veins were also correlated with poor EZ restoration and limited best corrected visual acuity (BCVA) improvements. In multivariate analysis, the number of macula-draining vortex vein (B = 0.197, p = 0.047) was a risk factor for worse BCVA at 12 months. Increased macula-draining vortex vein was related with unfavorable anatomical and poor visual outcomes after PDT in CSC patients.

Keywords: Central serous chorioretinopathy; Phachychoroid; Photodynamic therapy; Ultra-widefield; Vortex vein engorgement.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mean changes of functional and anatomical outcomes after photodynamic therapy. *Parameters that were significantly different between 3 groups using Kruskal-Wallis test.
Fig. 2
Fig. 2
Comparison of the photoreceptor recovery rate according to the macula-draining vortex veins.
See this image and copyright information in PMC

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