Lower your cholesterol early, and stick with it!

Affiliations

¹ Cardiovascular Research Institute, Friedman Brain Institute, Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. filip.swirski@mssm.edu.
² Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. christoph.binder@meduniwien.ac.at.

Comment

Filip K Swirski et al. Nat Rev Cardiol. 2025 Feb.

. 2025 Feb;22(2):69-70.

doi: 10.1038/s41569-024-01095-x.

¹ Cardiovascular Research Institute, Friedman Brain Institute, Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. filip.swirski@mssm.edu.
² Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. christoph.binder@meduniwien.ac.at.

No abstract available

Conflict of interest statement

Competing interests: The authors declare no competing interests.

Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.
Takaoka M, Zhao X, Lim HY, Magnussen CG, Ang O, Suffee N, Schrank PR, Ong WS, Tsiantoulas D, Sommer F, Mohanta SK, Harrison J, Meng Y, Laurans L, Wu F, Lu Y, Masters L, Newland SA, Denti L, Hong M, Chajadine M, Juonala M, Koskinen JS, Kähönen M, Pahkala K, Rovio SP, Mykkänen J, Thomson R, Kaisho T, Habenicht AJR, Clement M, Tedgui A, Ait-Oufella H, Zhao TX, Nus M, Ruhrberg C, Taleb S, Williams JW, Raitakari OT, Angeli V, Mallat Z. Takaoka M, et al. Nature. 2024 Oct;634(8033):457-465. doi: 10.1038/s41586-024-07993-x. Epub 2024 Sep 4. Nature. 2024. PMID: 39231480 Free PMC article.
Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming.
Lavillegrand JR, Al-Rifai R, Thietart S, Guyon T, Vandestienne M, Cohen R, Duval V, Zhong X, Yen D, Ozturk M, Negishi Y, Konkel J, Pinteaux E, Lenoir O, Vilar J, Laurans L, Esposito B, Bredon M, Sokol H, Diedisheim M, Saliba AE, Zernecke A, Cochain C, Haub J, Tedgui A, Speck NA, Taleb S, Mhlanga MM, Schlitzer A, Riksen NP, Ait-Oufella H. Lavillegrand JR, et al. Nature. 2024 Oct;634(8033):447-456. doi: 10.1038/s41586-024-07693-6. Epub 2024 Sep 4. Nature. 2024. PMID: 39232165 Free PMC article.

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