Association of MC1R variants with melanoma risk and interaction with sun exposure: An M-SKIP project

Irene Stefanaki¹, Oriana D'Ecclesiis², Silvano Vignati², Aurora Gaeta², Katerina Kypreou¹, Saverio Caini³, Sara Gandini², Eduardo Nagore⁴, Francesco Sera⁵, Francesca Botta², Julia Newton-Bishop⁶, David Polsky⁷, DeAnn Lazovich⁸, Peter A Kanetsky⁹, Susana Puig^{10

11}, Nelleke A Gruis¹², Maria Teresa Landi¹³, Maria Concetta Fargnoli¹⁴, Alexander Stratigos¹, Gabriella Guida¹⁵, Paola Ghiorzo^{16

17}, Chiara Menin¹⁸, José C García-Borrón¹⁹, Julian Little²⁰, Hongmei Nan²¹, Sara Raimondi²; M‐SKIP study group

Affiliations

¹ 1st Clinic of Dermatological and Venereal Diseases, Medical School National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athina, Greece.
² Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milano, Italy.
³ Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy.
⁴ Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain.
⁵ Department of Statistics, Computer Science and Applications G. Parenti, University of Florence, Florence, Italy.
⁶ Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
⁷ New York University School of Medicine, NYU Langone Medical Center, New York, New York, USA.
⁸ Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
⁹ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
¹⁰ Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
¹¹ CIBER de Enfermedades Raras, Barcelona, Spain.
¹² Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
¹³ Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA.
¹⁴ Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
¹⁵ Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari "A. Moro", Bari, Italy.
¹⁶ Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
¹⁷ IRCCS Ospedale Policlinico San Martino, Cancer Genetics, Genoa, Italy.
¹⁸ Diagnostic Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
¹⁹ Department of Biochemistry, Molecular Biology and Immunology, University of Murcia and IMIB-Arrixaca, Murcia, Spain.
²⁰ School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
²¹ Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.

PMID: 39425518
PMCID: PMC12008258 (available on 2026-07-01)
DOI: 10.1111/jdv.20380

Association of MC1R variants with melanoma risk and interaction with sun exposure: An M-SKIP project

Irene Stefanaki et al. J Eur Acad Dermatol Venereol. 2025 Jul.

. 2025 Jul;39(7):e568-e571.

doi: 10.1111/jdv.20380. Epub 2024 Oct 19.

Authors

Affiliations

¹ 1st Clinic of Dermatological and Venereal Diseases, Medical School National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athina, Greece.
² Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milano, Italy.
³ Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy.
⁴ Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain.
⁵ Department of Statistics, Computer Science and Applications G. Parenti, University of Florence, Florence, Italy.
⁶ Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
⁷ New York University School of Medicine, NYU Langone Medical Center, New York, New York, USA.
⁸ Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
⁹ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
¹⁰ Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
¹¹ CIBER de Enfermedades Raras, Barcelona, Spain.
¹² Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
¹³ Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA.
¹⁴ Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
¹⁵ Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari "A. Moro", Bari, Italy.
¹⁶ Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
¹⁷ IRCCS Ospedale Policlinico San Martino, Cancer Genetics, Genoa, Italy.
¹⁸ Diagnostic Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
¹⁹ Department of Biochemistry, Molecular Biology and Immunology, University of Murcia and IMIB-Arrixaca, Murcia, Spain.
²⁰ School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
²¹ Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.

PMID: 39425518
PMCID: PMC12008258 (available on 2026-07-01)
DOI: 10.1111/jdv.20380

No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: None declared.

References

1. Raimondi S, Sera F, Gandini S, Iodice S, Caini S, Maisonneuve P, et al. MC1R variants, melanoma and red hair color phenotype: a meta-analysis. Int J Cancer. 2008;122(12):2753–60. - PubMed
1. Landi MT, Kanetsky PA, Tsang S, Gold B, Munroe D, Rebbeck T, et al. MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population. Natl Cancer Inst. 2005;97(13):998–1007. - PubMed
1. Kanetsky PA, Panossian S, Elder DE, Guerry D, Ming ME, Schuchter L, et al. Does MC1R genotype convey information about melanoma risk beyond risk phenotypes? Cancer. 2010;116(10):2416–28. - PMC - PubMed
1. Kricker A, Armstrong BK, Goumas C, Kanetsky P, Gallagher RP, Begg CB, et al. MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study. Cancer Causes Control. 2010;21(12):2137–47. - PMC - PubMed
1. Raimondi S, Gandini S, Fargnoli MC, Bagnardi V, Maisonneuve P, Specchia C, et al. Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. BMC Med Res Methodol. 2012;12:116. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Association of MC1R variants with melanoma risk and interaction with sun exposure: An M-SKIP project

Affiliations

Association of MC1R variants with melanoma risk and interaction with sun exposure: An M-SKIP project

Authors

Affiliations

Conflict of interest statement

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources