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. 2025 Jan;80(1):335-338.
doi: 10.1111/all.16365. Epub 2024 Oct 19.

Redefining tryptase norms in the pediatric population reveals sex-based differences: Clinical implications

Mathilde Puel  1 , Julien Rossignol  2   3 , Clotilde Devin  2 , Marine Madrange  2 , Antoine Diep  1 , Pascale Nicaise Roland  1 , Sylvie Chollet-Martin  1 , Julien Husson  4 , Olivier Hermine  2   3 , Christine Bodemer  2   5 , Chantal Brouzes  6 , Luc De Chaisemartin  1 , Laura Polivka  2   5 ; CEREMAST network
Affiliations

Redefining tryptase norms in the pediatric population reveals sex-based differences: Clinical implications

Mathilde Puel et al. Allergy. 2025 Jan.
No abstract available

Keywords: hereditary alpha‐tryptasemia; mast cells; pediatric allergy; serum basal tryptase.

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Conflict of interest statement

The authors declare no conflicts of interest with regard to the present study.

Figures

FIGURE 1
FIGURE 1
Serum baseline tryptase levels by age in the study cohort. sBT levels are represented by age group in ng/mL. The red dot line represents the 8.0 ng/mL threshold used in adult population for screening of HαT. ***p < 0.001
FIGURE 2
FIGURE 2
Median sBT levels by age in an overall pediatric cohort (A), in males (B) and in females (C). Error bars represent 95% CI. Median sBT levels are represented for male (grey squares) and female (black circles). The red line corresponds to the tryptase threshold for detecting HαT in A and B, and the suggested threshold in C.
See this image and copyright information in PMC

References

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