Dominance of mutations in epigenetic regulators and a diversity of signaling alterations in blast-phase BCR::ABL1-negative myeloproliferative neoplasms

Petruta Gurban^{1

2}, Cristina Mambet^{1

3

4}, Anca Botezatu⁵, Laura G Necula¹, Lilia Matei¹, Ana Iulia Neagu^{1

6}, Ioana Pitica¹, Marius Ataman¹, Aurelia Tatic^{1

3

7}, Alexandru Bardas^{1

3

7}, Mihnea A Gaman^{1

3

7}, Camelia Dobrea^{3

7}, Mihaela Dragomir⁷, Cecilia Ghimici⁸, Silvana Angelescu^{3

8}, Doina Barbu⁸, Oana Stanca^{3

8}, Marina Danila⁸, Nicoleta Berbec^{3

8}, Andrei Colita^{3

8}, Ana Maria Vladareanu^{3

4}, Saviana Nedeianu¹, Mihaela Chivu-Economescu¹, Coralia Bleotu¹, Daniel Coriu^{1

3

7}, Elise Sepulchre⁹, Gabriela Anton⁵, Carmen C Diaconu¹, Stefan N Constantinescu^{9

10

11

12}

Affiliations

¹ Cellular and Molecular Pathology Department, Stefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania.
² Cytogenomic Medical Laboratory, Bucharest, Romania.
³ Department of Radiology, Oncology, and Hematology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
⁴ Hematology Department, Emergency University Clinical Hospital, Bucharest, Romania.
⁵ Molecular Virology Department, Stefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania.
⁶ Infectious Diseases, Epidemiology, Microbiology, Parasitology, Virology, Diabetes, Endocrinology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
⁷ Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
⁸ Hematology Department, Coltea Clinical Hospital, Bucharest, Romania.
⁹ de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
¹⁰ SIGN (Cell Signalling and Molecular Hematology), Ludwig Institute for Cancer Research Brussels, Brussels, Belgium.
¹¹ Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium.
¹² Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Oxford University, Oxford, UK.

Petruta Gurban et al. Am J Hematol. 2025 Jan.

. 2025 Jan;100(1):168-171.

doi: 10.1002/ajh.27503. Epub 2024 Oct 19.

¹ Cellular and Molecular Pathology Department, Stefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania.
² Cytogenomic Medical Laboratory, Bucharest, Romania.
³ Department of Radiology, Oncology, and Hematology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
⁴ Hematology Department, Emergency University Clinical Hospital, Bucharest, Romania.
⁵ Molecular Virology Department, Stefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania.
⁶ Infectious Diseases, Epidemiology, Microbiology, Parasitology, Virology, Diabetes, Endocrinology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
⁷ Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
⁸ Hematology Department, Coltea Clinical Hospital, Bucharest, Romania.
⁹ de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
¹⁰ SIGN (Cell Signalling and Molecular Hematology), Ludwig Institute for Cancer Research Brussels, Brussels, Belgium.
¹¹ Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium.
¹² Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Oxford University, Oxford, UK.

No abstract available

Publication types