CUTting through the distance: A disease-relevant long-range ONECUT1 enhancer
- PMID: 39427317
- DOI: 10.1016/j.celrep.2024.114897
CUTting through the distance: A disease-relevant long-range ONECUT1 enhancer
Abstract
In two recent issues of Cell Reports, Kaplan et al.1 and Merz et al.2 identify a distal enhancer region within the OC1 gene and demonstrate its relevance to OC1 expression, pancreatic endocrine differentiation, and diabetes susceptibility.
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
-
CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant.Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640. Epub 2024 Aug 21. Cell Rep. 2024. PMID: 39163202 Free PMC article.
-
A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes.Cell Rep. 2024 Nov 26;43(11):114853. doi: 10.1016/j.celrep.2024.114853. Epub 2024 Oct 19. Cell Rep. 2024. PMID: 39427318
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources