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. 2024 Sep 1;27(5):571-572.
doi: 10.4103/aian.aian_364_24. Epub 2024 Oct 21.

Melanin Incontinence, Infantile Stroke, and Negative Genetics in a Case of Incontinentia Pigmenti

Sangeeth Thuppanattumadam Ananthasubramanian  1 , Seemikeri Chinmayi Chanrakant  1 , Tumulu Seetam Kumar  2 , Rangasamy Thiruvengadam Rajeswarie  3 , Gautham Arunachal Udupi  4 , Raghavendra Kenchiah  1 , Hansashree Padmanabha  1
Affiliations

Melanin Incontinence, Infantile Stroke, and Negative Genetics in a Case of Incontinentia Pigmenti

Sangeeth Thuppanattumadam Ananthasubramanian et al. Ann Indian Acad Neurol. .
No abstract available

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Hyperpigmentation along the lines of Blaschko (Stage 3 of IP) noted over the back. (b) Hyperpigmentation along the lines of Blaschko over the posterior aspect of thighs and legs. (c) Hypodontia (no conical/abnormally shaped teeth were seen). IP: incontinentia pigmenti
Figure 2
Figure 2
(a) Skin biopsy (HE, ×400) shows melanin incontinence in the superficial dermis (white arrow). (b) Sagittal FLAIR MRI depicting atrophied corpus callosum (yellow arrow). (c) Coronal FLAIR MRI showing left frontal encephalomalacia with gliosis along the corticospinal tract in the internal capsule and ipsilateral hemi crus atrophy. (d) and (e) Axial FLAIR MRI showing cystic encephalomalacia with gliosis in the left frontoparietal and occipital lobes with ex vacuo dilation of the left lateral ventricle as well as right medial frontal gliosis. (f) TOF MR angiography depicting attenuation of left middle cerebral arterial M2, M3 branches. FLAIR: fluid attenuated inversion recovery, HE: hematoxylin and eosin, MR: magnetic resonance, MRI: magnetic resonance imaging, TOF: Time of flight
See this image and copyright information in PMC

References

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