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. 2024 Feb 1;53(1):dyad165.
doi: 10.1093/ije/dyad165.

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study

Omer Elneima  1 Hamish J C McAuley  1 Olivia C Leavy  1   2 James D Chalmers  3 Alex Horsley  4   5 Ling-Pei Ho  6   7 Michael Marks  8   9 Krisnah Poinasamy  10 Betty Raman  7   11 Aarti Shikotra  1 Amisha Singapuri  1 Marco Sereno  1 Victoria C Harris  1 Linzy Houchen-Wolloff  12   13 Ruth M Saunders  1 Neil J Greening  1 Matthew Richardson  1 Jennifer K Quint  14 Andrew Briggs  15 Annemarie B Docherty  16 Steven Kerr  16   17 Ewen M Harrison  16 Nazir I Lone  16   18 Mathew Thorpe  16 Liam G Heaney  19   20 Keir E Lewis  21   22 Raminder Aul  23 Paul Beirne  24 Charlotte E Bolton  25   26 Jeremy S Brown  27 Gourab Choudhury  18   28 Nawar Diar Bakerly  29   30 Nicholas Easom  31   32 Carlos Echevarria  33   34 Jonathan Fuld  35   36 Nick Hart  37 John R Hurst  27   38 Mark G Jones  39   40 Dhruv Parekh  41   42 Paul Pfeffer  43   44 Najib M Rahman  7   45 Sarah L Rowland-Jones  46   47 Aa Roger Thompson  46   47 Caroline Jolley  48   49 Ajay M Shah  49   50 Dan G Wootton  51   52 Trudie Chalder  53   54 Melanie J Davies  55   56 Anthony De Soyza  33   57 John R Geddes  7   58 William Greenhalf  52   59 Simon Heller  60 Luke S Howard  14   61 Joseph Jacob  62   63 R Gisli Jenkins  14 Janet M Lord  64   65 William D-C Man  66   67 Gerry P McCann  56   68 Stefan Neubauer  11   45 Peter Jm Openshaw  14 Joanna C Porter  27 Matthew J Rowland  69 Janet T Scott  70 Malcolm G Semple  51   71 Sally J Singh  1   12 David C Thomas  72 Mark Toshner  36   73 Nikki Smith  74 Aziz Sheikh  16 Christopher E Brightling  1 Louise V Wain  1   2 Rachael A Evans  1 PHOSP-COVID Collaborative Group
Collaborators, Affiliations

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study

Omer Elneima et al. Int J Epidemiol. .
No abstract available

Keywords: COVID-19; comorbidities; symptoms.

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Conflict of interest statement

A.She has served on a number of UK and Scottish Government COVID-19 advisory bodies; all these roles were unremunerated. C.E.B. declares that their institute was awarded a grant from UKRI/NIHR to complete this work; the author reports grants from GlaxoSmithKline, AstraZeneca, Sanofi, Regeneron, Boehringer Ingelheim, Chiesi, Novartis, Roche, Genentech, Mologic and 4DPharma; and consultancy fees paid to their institution from GlaxoSmithKline, AstraZeneca, Sanofi, Boehringer Ingelheim, Chiesi, Novartis, Roche, Genentech, Mologic, 4DPharma and Areteia. C.E.Bo declares that their institute was awarded a grant from the UK Research and Innovation UKRI/NIHR and institutional support from NIHR Nottingham BRC to complete this work; the author reports grants from Nottingham University Hospitals (NUH) Charity, University of Nottingham charitable donation and NUH Research and Innovation Department. J.C.P. declares consultancy fees for Istesso and Tacit Fusion and speaker’s honorarium for The Limbic, outside the submitted work. P.P. declares grants from NIHR to the institute to support a study of digital remote rehabilitation after COVID-19. D.G.W. is supported by an NIHR Advanced Fellowship NIHR300669. S.H. declares receiving consultancy fees from Zealand Pharma and Zucara Pharma, research support from Dexcom Inc. and speaker fees from Medtronic and NovoNordisk, outside the submitted work. S.H. also declares chairing the DSMC for Eli Lilly. R.A. received lecture fees and sponsorship to attend conferences from Boehringer Ingelheim, outside the submitted work. R.A.E. reports grants from GlaxoSmithKline and Wolfson Foundation during the conduct of the study; travel and speaker fees from AstraZeneca, Boehringer Ingelheim and Chiesi, outside the submitted work. All other authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Consort diagram of the Post-Hospitalisation COVID-19 (PHOSP-COVID) study. aThe wide range window for the first research visit (2–7 months) was deliberately chosen to accommodate the variation in planned clinical follow-up appointments across the different participating sites and to allow the research visit to coincide with the planned clinical follow-up appointments
Figure 2.
Figure 2.
Illustration of the four cluster phenotypes of mental, cognitive and physical health impairments with associated inflammatory biomarkers. The figure shows the distribution of the four recovery cluster phenotypes and the list of identified proteins that were significantly differentially expressed (compared with the reference mild cluster) after FDR adjustment. FDR, false detection rate; IL-6, interleukin-6; TFF2, trefoil factor 2; TGFA, transforming growth factor α; LAMP3, lysosomal associated membrane protein 3; CD83, CD83 molecule; LGALS9, galectin-9; PLAUR, urokinase plasminogen activator surface receptor; EPO, erythropoietin; FLT3LG, FMS-related receptor tyrosine kinase 3 ligand; AGRN, agrin; SCGB3A2, secretoglobin family 3A member 2; FST, follistatin; CLEC4D, C-type lectin domain family 4 member D; CD70, CD70 molecule
Figure 3.
Figure 3.
Modular approach to the clinical care and phenotyping with the different working groups of the Post-Hospitalisation COVID-19 (PHOSP-COVID) consortium. MDT, multidisciplinary team; PPI, patient and public involvement

References

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