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Review
. 2024 Sep 19;16(9):e69697.
doi: 10.7759/cureus.69697. eCollection 2024 Sep.

Updates on the Association Between Vitiligo and Thyroid Diseases: A Systematic Review

Riyad M Abuhalimeh  1 , Layan Saeed Alshmrani  2 , Nourah Abdullah  3 , Assem Mubarak H Alqahtani  4 , Sereen Dhafer AlQarni  5 , Mohannad Muaid Aljuaid  6 , Waleed Khalid Z Alghuyaythat  7 , Saud Sheher Mohammed Alkahtani  8 , Afnan F Aljawi  9 , Ghena Mahir Abdulrahman Alsaadi  10
Affiliations
Review

Updates on the Association Between Vitiligo and Thyroid Diseases: A Systematic Review

Riyad M Abuhalimeh et al. Cureus. .

Abstract

The main objective of this study is to estimate the prevalence of thyroid diseases in patients with vitiligo and investigate the potential shared autoimmune mechanisms underlying the co-occurrence of vitiligo and thyroid diseases. To locate research that met the inclusion criteria, a thorough computerized search of relevant databases was carried out. A comprehensive search was carried out on PubMed, SCOPUS, Science Direct, and Web of Science to locate relevant material. Our data included 13 trials with 82,230 participants, and 40,116 (48.8%) of them were males. The prevalence of thyroid disorders ranged from 3.2% to 32.1%, with a total prevalence of 2,906 (3.5%). Vitiligo patients are more likely to have a number of immunological comorbidities, underscoring the serious effects of the illness on overall health, especially thyroid disorders. The correlation between vitiligo and positive thyroid peroxidase antibodies, hypothyroidism, and autoimmune thyroiditis is notably high. We found a strong association between vitiligo and the incidence of thyroid disorders, particularly autoimmune thyroid disorders. The findings emphasize the necessity of identifying and treating thyroid dysfunction in vitiligo patients, as it might affect the clinical course of the skin condition and overall patient health. Future research is required to standardize study methodology, investigate underlying mechanisms, and create integrated therapy and screening regimens.

Keywords: autoimmune comorbidity; depigmentation; systematic review; thyroid disorders; vitiligo.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram is used to summarize the study decisions.
See this image and copyright information in PMC

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