Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome

David Massicotte Azarniouch¹, Daniel J Crona², Priscilla Karnabi³, Bhadran Bose⁴, Patrick H Nachman⁵, Marc Carrier^{6

7}, Mark Canney¹, David W Johnson⁸, Taewoo Lee⁹, Raja Ramachandran¹⁰, Vivekanand Jha^{11

12

13}, Nigel S Key¹⁴, Vimal K Derebail¹⁵

Affiliations

¹ Division of Nephrology, Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
² Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
³ Clinical Epidemiology Program, the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
⁴ Department of Nephrology, Nepean Hospital, Kingswood, New South Wales, Australia.
⁵ Division of Nephrology and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
⁶ Department of Medicine, University of Ottawa at The Ottawa Hospital, Ottawa, Ontario, Canada.
⁷ The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
⁸ Department of Kidney and Transplant Services, University of Queensland at Princess Alexandra Hospital, Brisbane, Queensland, Australia.
⁹ Division of Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
¹⁰ Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
¹¹ George Institute for Global Health, University of New South Wales, New Delhi, India.
¹² School of Public Health, Imperial College, London, UK.
¹³ Prasanna School of Public Health, Manipal Academy of Medical Education, Manipal, India.
¹⁴ Division of Hematology, Department of Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
¹⁵ Division of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

PMID: 39430178
PMCID: PMC11489394
DOI: 10.1016/j.ekir.2024.07.013

Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome

David Massicotte Azarniouch et al. Kidney Int Rep. 2024.

. 2024 Jul 19;9(10):3053-3056.

doi: 10.1016/j.ekir.2024.07.013. eCollection 2024 Oct.

Authors

Affiliations

¹ Division of Nephrology, Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
² Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
³ Clinical Epidemiology Program, the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
⁴ Department of Nephrology, Nepean Hospital, Kingswood, New South Wales, Australia.
⁵ Division of Nephrology and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
⁶ Department of Medicine, University of Ottawa at The Ottawa Hospital, Ottawa, Ontario, Canada.
⁷ The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
⁸ Department of Kidney and Transplant Services, University of Queensland at Princess Alexandra Hospital, Brisbane, Queensland, Australia.
⁹ Division of Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
¹⁰ Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
¹¹ George Institute for Global Health, University of New South Wales, New Delhi, India.
¹² School of Public Health, Imperial College, London, UK.
¹³ Prasanna School of Public Health, Manipal Academy of Medical Education, Manipal, India.
¹⁴ Division of Hematology, Department of Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
¹⁵ Division of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

PMID: 39430178
PMCID: PMC11489394
DOI: 10.1016/j.ekir.2024.07.013

Erratum in

Erratum to "Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome" [Kidney International Reports Volume 9, Issue 10, October 2024, Pages 3053-3056].
Massicotte-Azarniouch D, Crona DJ, Karnabi P, Bose B, Nachman PH, Carrier M, Canney M, Johnson DW, Lee T, Ramachandran R, Jha V, Key NS, Derebail VK. Massicotte-Azarniouch D, et al. Kidney Int Rep. 2025 Jan 31;10(4):1301. doi: 10.1016/j.ekir.2025.01.043. eCollection 2025 Apr. Kidney Int Rep. 2025. PMID: 40303221 Free PMC article.

No abstract available

Keywords: anticoagulation; nephrotic syndrome; survey.

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Figures

**Figure 1**
Choice of anticoagulant and dose in nephrotic syndrome, when a decision is made to anticoagulate. DOAC, direct oral anticoagulant; LMWH, low-molecular weight heparin.

See this image and copyright information in PMC

References

1. Barbour S.J., Greenwald A., Djurdjev O., et al. Disease-specific risk of venous thromboembolic events is increased in idiopathic glomerulonephritis. Kidney Int. 2012;81:190–195. doi: 10.1038/ki.2011.312. - DOI - PubMed
1. Gyamlani G., Molnar M.Z., Lu J.L., Sumida K., Kalantar-Zadeh K., Kovesdy C.P. Association of serum albumin level and venous thromboembolic events in a large cohort of patients with nephrotic syndrome. Nephrol Dial Transplant. 2017;32:157–164. doi: 10.1093/NDT/GFW227. - DOI - PMC - PubMed
1. Lionaki S., Derebail V.K., Hogan S.L., et al. Venous thromboembolism in patients with membranous nephropathy. Clin J Am Soc Nephrol. 2012;7:43–51. doi: 10.2215/CJN.04250511. - DOI - PMC - PubMed
1. Rovin B.H., Adler S.G., Barratt J., et al. KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int. 2021;100:S1–S276. doi: 10.1016/J.KINT.2021.05.021. - DOI - PubMed
1. Derebail V.K., Zhu J., Crawford M.L., et al. Pharmacokinetics and Pharmacodynamics of Apixaban in nephrotic syndrome: findings from a Phase 1a Trial. Am J Kidney Dis. 2023;81:373–376. doi: 10.1053/j.ajkd.2022.09.011. - DOI - PMC - PubMed

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Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome

Affiliations

Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome

Authors

Affiliations

Erratum in

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References

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