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Review
. 2024 Oct 21;51(1):1085.
doi: 10.1007/s11033-024-10021-w.

Potential hypothesis for the increased risk of Parkinson´s disease following COVID-19

Raffaella Mormile  1 , Cristina Mormile  2 , Carmine Picone  3   4
Affiliations
Review

Potential hypothesis for the increased risk of Parkinson´s disease following COVID-19

Raffaella Mormile et al. Mol Biol Rep. .

Abstract

Patients with severe COVID-19 may be more likely to develop PD as a result of shared biological pathways including a great expansion of MDSCs and an imbalance in Th17/Tregs ratio. We think that these shared pathogenic features may mechanistically explain the COVID-19 - PD axis. Thus, we assume that patients who recovered from critical COVID-19 should be selected based upon a potential higher risk of developing PD. Further studies are needed to better define the possible relationship between COVID-19 and neuroinflammation and identify whether some people are more likely to develop PD after contracting COVID-19 than others with special emphasis to ascertain possible vulnerable genetic backgrounds or epigenetic factors acting on brain which may promote PD during SARS COV-2 infection. Finally, we think that regular physical activity should be performed and encouraged in patients with PD.

Keywords: COVID-19; MDSCs; Parkinson’s disease; Th17 cells; Tregs.

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References

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