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Case Reports
. 2024 Jan-Dec:12:23247096241292213.
doi: 10.1177/23247096241292213.

Clostridium paraputrificum in a Middle-Aged Male With Liver Disease

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Case Reports

Clostridium paraputrificum in a Middle-Aged Male With Liver Disease

Kevin Trong Dao et al. J Investig Med High Impact Case Rep. 2024 Jan-Dec.

Abstract

Clostridium paraputrificum is a gram-positive anaerobic spore-forming bacillus with a pathological prevalence of <1% among all Clostridium species. However, despite being a rare bacterium, there have been reported cases of C paraputrificum causing a wide range of varying pathologies. Herein presented is a case of cirrhosis secondary to alcoholism complicated by developing C paraputrificum bacteremia suspected due to gastrointestinal mucosal damage. There is literature demonstrating certain comorbid conditions having an impact on the overall prognosis of patients with C paraputrificum bacteremia.

Keywords: Clostridium paraputrificum; anaerobic; cirrhosis; comorbid conditions; mucosal.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Image 1.
Image 1.
CT scan of abdomen showing free fluid and moderate amount of ascites. Paracentesis fluid analysis did not find evidence of spontaneous bacterial peritonitis.
Image 2.
Image 2.
Blood culture gram stain showing gram positive rods as indicated by the yellow arrow.
Image 3.
Image 3.
Anaerobic culture media showing colony morphology of Clostridium paraputrificum (ViTek2, bioMérieux).

References

    1. Kiu R, Caim S, Alcon-Giner C, et al. Preterm infant-associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum strains: genomic and evolutionary insights. Genome Biol Evol. 2017;9(10):2707-2714. - PMC - PubMed
    1. Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014;146(6):1564-1572. - PMC - PubMed
    1. Smith B, Bodé S, Petersen BL, et al. Community analysis of bacteria colonizing intestinal tissue of neonates with necrotizing enterocolitis. BMC Microbiol. 2011;11:73. - PMC - PubMed
    1. Shandera WX, Humphrey RL, Stratton LB. Necrotizing enterocolitis associated with Clostridium paraputrificum septicemia. South Med J. 1988;81(2):283-284. - PubMed
    1. Leal J, Gregson DB, Ross T, Church DL, Laupland KB. Epidemiology of Clostridium species bacteremia in Calgary, Canada, 2000-2006. J Infect. 2008;57(3):198-203. - PubMed

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