Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

Valentine Poissonnet¹, Emilien Chabrillac², Emmanuelle Uro-Coste³, Virginie Woisard², Antoine Moya-Plana⁴, Florent Espitalier⁵, Joel Castelli⁶, Thibault Dedieu⁷, Sébastien Salas⁸, Renaud Garrel⁹, Robin Baudouin¹⁰, Gilles Poissonnet¹¹, Claire Castain¹², Jonathan Barbut¹³, Haitham Mirghani¹⁴, Diane Evrard¹⁵, Olivier Bouchain¹⁶, Jean Paul Marie¹⁷, Hélène Orliac¹⁸, Philippe Ceruse¹⁹, Xavier Dufour²⁰, Esteban Brenet²¹, Audrey Rambeau²², Philippe Herman²³, Yazan Abu Shama²⁴, Chloé Bertolus²⁵, Sarah Atallah²⁶, Sylvain Morinière²⁷, Christian Righini²⁸, François Mouawad²⁹, Suzy Duflo³⁰, Bertille Segier³¹, Sébastien Vergez²

Affiliations

¹ Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France. Electronic address: valentine.poissonnet@gmail.com.
² Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.
³ Department of Anatomical Pathology, University Cancer Institute Toulouse, Toulouse France.
⁴ Head and Neck Oncology Department, Gustave-Roussy Institute, Villejuif, France.
⁵ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nantes, France.
⁶ Department of Radiation Oncology, Centre Eugene Marquis, Rennes, France.
⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Strasbourg, France.
⁸ AP-HM, Aix-Marseille University, Department of Medical Oncology, Marseille, France.
⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Montpellier, France.
¹⁰ Otolaryngology, Head and Neck Surgery Department, Foch Hospital, Paris, France.
¹¹ Otolaryngology, Head and Neck Surgery Department, Head and Neck University Institute, Nice, France.
¹² Department of Anatomical Pathology, Bordeaux University Hospital-CHU, F-33000, Bordeaux, France.
¹³ Otolaryngology, Head and Neck Surgery Department, Hospital of Toulon, France.
¹⁴ Otolaryngology, Head and Neck Surgery Department, George Pompidou European Hospital, Paris, France.
¹⁵ Otolaryngology, Head and Neck Surgery Department, Bichat Hospital, Paris, France.
¹⁶ Head and Neck Surgery Department, CHU Sart Tilman, University Liege, Belgium.
¹⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Rouen, France.
¹⁸ Department of Radiation Therapy, University Hospital of Limoges, France.
¹⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lyon, France.
²⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Poitiers, France.
²¹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Reims, France.
²² Oncology Department, François Baclesse Centre, Caen, France.
²³ Otolaryngology, Head and Neck Surgery Department, Lariboisière Hospital, 2 rue Ambroise Paré, 75010 Paris, France.
²⁴ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nancy, France.
²⁵ Department of Oral and Maxillo-Facial Surgery, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université, France.
²⁶ Head and Neck Surgery Department, Tenon Hospital, APHP, Sorbonne University, Paris, France.
²⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Tours, France.
²⁸ Otolaryngology, Head and Neck Surgery Department, University Hospital of Grenoble, France.
²⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lille, France.
³⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Point-à-Pitre, France.
³¹ Statistical Department, Institut Claudius Regaud, University Institute of Cancer, Toulouse, France.

PMID: 39432991
DOI: 10.1016/j.oraloncology.2024.107072

Free article

Multicenter Study

Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

Valentine Poissonnet et al. Oral Oncol. 2024 Dec.

Free article

. 2024 Dec:159:107072.

doi: 10.1016/j.oraloncology.2024.107072. Epub 2024 Oct 20.

Authors

Affiliations

¹ Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France. Electronic address: valentine.poissonnet@gmail.com.
² Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.
³ Department of Anatomical Pathology, University Cancer Institute Toulouse, Toulouse France.
⁴ Head and Neck Oncology Department, Gustave-Roussy Institute, Villejuif, France.
⁵ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nantes, France.
⁶ Department of Radiation Oncology, Centre Eugene Marquis, Rennes, France.
⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Strasbourg, France.
⁸ AP-HM, Aix-Marseille University, Department of Medical Oncology, Marseille, France.
⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Montpellier, France.
¹⁰ Otolaryngology, Head and Neck Surgery Department, Foch Hospital, Paris, France.
¹¹ Otolaryngology, Head and Neck Surgery Department, Head and Neck University Institute, Nice, France.
¹² Department of Anatomical Pathology, Bordeaux University Hospital-CHU, F-33000, Bordeaux, France.
¹³ Otolaryngology, Head and Neck Surgery Department, Hospital of Toulon, France.
¹⁴ Otolaryngology, Head and Neck Surgery Department, George Pompidou European Hospital, Paris, France.
¹⁵ Otolaryngology, Head and Neck Surgery Department, Bichat Hospital, Paris, France.
¹⁶ Head and Neck Surgery Department, CHU Sart Tilman, University Liege, Belgium.
¹⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Rouen, France.
¹⁸ Department of Radiation Therapy, University Hospital of Limoges, France.
¹⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lyon, France.
²⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Poitiers, France.
²¹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Reims, France.
²² Oncology Department, François Baclesse Centre, Caen, France.
²³ Otolaryngology, Head and Neck Surgery Department, Lariboisière Hospital, 2 rue Ambroise Paré, 75010 Paris, France.
²⁴ Otolaryngology, Head and Neck Surgery Department, University Hospital of Nancy, France.
²⁵ Department of Oral and Maxillo-Facial Surgery, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université, France.
²⁶ Head and Neck Surgery Department, Tenon Hospital, APHP, Sorbonne University, Paris, France.
²⁷ Otolaryngology, Head and Neck Surgery Department, University Hospital of Tours, France.
²⁸ Otolaryngology, Head and Neck Surgery Department, University Hospital of Grenoble, France.
²⁹ Otolaryngology, Head and Neck Surgery Department, University Hospital of Lille, France.
³⁰ Otolaryngology, Head and Neck Surgery Department, University Hospital of Point-à-Pitre, France.
³¹ Statistical Department, Institut Claudius Regaud, University Institute of Cancer, Toulouse, France.

PMID: 39432991
DOI: 10.1016/j.oraloncology.2024.107072

Abstract

Introduction: Salivary carcinomas of the tongue represent a therapeutic challenge as their radical excision is particularly mutilating. We aimed to study the oncologic and functional outcomes of advanced stages salivary carcinomas of the tongue.

Materials and methods: This retrospective multicentric study, based on the French national network on rare head and neck cancers (REFCOR), included all patients with a T3-T4 salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018.

Results: In total, 47 patients were included, of which 44.7 % underwent surgery. Histologies were mostly adenoid cystic carcinomas (61.7 %), followed by other adenocarcinomas (27.7 %) and mucoepidermoid carcinomas (10.6 %). Median follow-up duration was 63.9 months. In multivariable analysis, surgery was significantly associated with better Recurrence-Free Survival (HR = 0.23, 95 %CI [0.09;0.55]) and Local/Regional Recurrence-Free Survival (HR = 0.31, 95 %CI [0.10;0.95]). The rate of distant metastasis at the end of follow-up was 61.9 % in the surgical group and 57.7 % in the non-surgical group. The Distant Metastasis Free Survival was 54.9 % [38.3;68.7], without statistical difference between both groups. There were similar rates of definitive gastrostomies but the rate of normal oral diet at the last follow-up seemed higher in the surgery group (38.1 % vs 15.4 %).

Conclusion: Radical surgery in that population mainly aims to improve local/regional control, which may result in better long-term swallowing functions. About half of these tumors may be associated with occult distant metastasis at initial presentation. More studies are warranted to establish the role of postoperative RT and non-surgical treatment with concurrent CRT.

Keywords: Locally-advanced stage; Minor salivary gland; Salivary gland carcinoma; Tongue; Totalglossectomy.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

Affiliations

Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

LinkOut - more resources

Full Text Sources