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. 2024 Oct 21;24(1):524.
doi: 10.1186/s12890-024-03327-9.

Economic burden of short-acting beta-2 agonist (SABA) overuse among asthma patients in Türkiye: a cost analysis with respect to the updated GINA treatment recommendations

Arzu Yorgancıoğlu  1 , Kurtuluş Aksu  2 , Ceyhun Cura  3 , Yiğit Yaman  4 , Melda Dinç  4 , Simten Malhan  5 ; SABINA Türkiye Study Group*
Collaborators, Affiliations

Economic burden of short-acting beta-2 agonist (SABA) overuse among asthma patients in Türkiye: a cost analysis with respect to the updated GINA treatment recommendations

Arzu Yorgancıoğlu et al. BMC Pulm Med. .

Abstract

Background: This cost of illness study aimed to determine economic burden of short-acting β2-agonist (SABA) overuse in Türkiye from payer perspective with respect to the updated GINA 2022 treatment recommendations.

Methods: A total of 3,034,879 asthma patients comprised the study population, via estimations extrapolated from the Türkiye arm of the global SABINA III study. The economic burden (costs related to the drug use and severe exacerbations) was compared in subgroups of overall (≥ 0 canisters/year) vs. GINA-recommended (0-2 canisters/year, hypothetical population) SABA use and in subgroups of appropriate use (0-2 canisters/year, real population) vs. overuse (≥ 3 canisters/year) of SABA with extrapolation of SABINA Türkiye data to the Türkiye asthma population.

Results: Recommended SABA use was predicted to prevent 127,505 of 157,512 severe exacerbations per year in mild asthma patients and 2,668,916 of 3,262,800 severe exacerbations per year in moderate-severe asthma patients. Annual cost burden of not applying recommended SABA use (overall [≥ 0 canisters/year] vs. GINA-recommended [0-2 canisters/year] SABA use) in mild asthma and moderate-severe asthma patients was calculated to be €20.43 million and €427.65 million in terms of severe exacerbations, and to be €829,352 and €7.20 million in terms of drug costs, respectively. The total annual economic burden arising from not applying recommended SABA use was estimated to be €456.11 million. Appropriate use (0-2 canisters/year) vs. overuse (≥ 3 canisters/year) of SABA was associated with decreased frequency of severe exacerbations per year in mild asthma (from 129,878 to 27,634) and moderate-severe asthma (from 2,834,611 to 428,189) patients. SABA overuse in mild and moderate-severe asthma patients was estimated to yield an additional annual cost of €16.38 million and €385.59 million, respectively in terms of severe exacerbations, and a total €11.30 million additional drug cost. The overall annual economic burden arising from SABA overuse was estimated to be €413.27 million.

Conclusions: The estimated annual total economic burden arising from not applying recommended SABA use (€456.11 million) and SABA overuse (€413.27 million) with respect to the updated GINA 2022 treatment recommendations indicates the substantial cost burden of SABA overuse to the Turkish National Health System, corresponding up to 26% of the total direct cost of asthma reported in our country.

Keywords: Adult asthma; Asthma severity; Cost analysis; Cost burden; Direct costs; GINA updates; SABA overuse; Türkiye.

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Conflict of interest statement

AY has received research grants from MSD, AstraZeneca and Sanofi as a principal investigator/collaborator, received honoraria from AstraZeneca, Abdi İbrahim, GSK, Novartis Sandoz, Sanofi and Chiesi, and served as a consultant/advisory member for AstraZeneca, GSK, Novartis, Sanofi, Chiesi and Deva; KA has received research support from Sanofi, AstraZeneca, Health Institutes of Türkiye (TUSEB) and received consulting or scientific speaking fees from AstraZeneca, GlaxoSmithKline, Novartis, Sandoz, Chiesi, İbrahim Etem, Abdi İbrahim, Deva and Acino; CC is an employee of AstraZeneca Türkiye; YY is an employee of AstraZeneca Türkiye; MD is an employee of AstraZeneca Türkiye; SM has received research grants from AstraZeneca.

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