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Review
. 2025 Jan;240(1):e31469.
doi: 10.1002/jcp.31469. Epub 2024 Oct 21.

RHO subfamily of small GTPases in the development and function of hematopoietic cells

Stephany Suelen de Castro Sampaio  1 , Maria Carolina Clares Ramalho  1 , Caroline Santos de Souza  1 , Beatriz de Almeida Rodrigues  1 , Guilherme Ramos Sales de Mendonça  1 , Mariana Lazarini  1
Affiliations
Review

RHO subfamily of small GTPases in the development and function of hematopoietic cells

Stephany Suelen de Castro Sampaio et al. J Cell Physiol. 2025 Jan.

Abstract

RHOA, RHOB, and RHOC comprise a subfamily of RHO GTPase proteins famed for controlling cytoskeletal dynamics. RHO proteins operate downstream of multiple signals emerging from the microenvironment, leading to diverse cell responses, such as proliferation, adhesion, and migration. Therefore, RHO signaling has been centrally placed in the regulation of blood cells. Despite their high homology, unique roles of RHOA, RHOB, and RHOC have been described in hematopoietic cells. In this article, we overview the contribution of RHO proteins in the development and function of each blood cell lineage. Additionally, we highlight the aberrations of the RHO signaling pathways found in hematological malignancies, providing clues for the identification of new therapeutic targets.

Keywords: RHO GTPases; RHOA; RHOB; RHOC; hematopoiesis.

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References

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