Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Feb;599(4):466-475.
doi: 10.1002/1873-3468.15041. Epub 2024 Oct 22.

Expression and function of interferon lambda receptor 1 variants

Laura A Novotny  1 , Eric G Meissner  1   2
Affiliations
Review

Expression and function of interferon lambda receptor 1 variants

Laura A Novotny et al. FEBS Lett. 2025 Feb.

Abstract

Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell-type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.

Keywords: IFNLR1; innate immunity; interferon lambda; receptor isoforms.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

The authors declare no conflict of interest.

References

    1. Renauld JC (2003) Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators, Nat Rev Immunol. 3, 667–76. - PubMed
    1. Langer JA, Cutrone EC & Kotenko S (2004) The Class II cytokine receptor (CRF2) family: overview and patterns of receptor-ligand interactions, Cytokine Growth Factor Rev. 15, 33–48. - PubMed
    1. Lazear HM, Schoggins JW & Diamond MS (2019) Shared and Distinct Functions of Type I and Type III Interferons, Immunity. 50, 907–923. - PMC - PubMed
    1. Stanifer ML, Guo C, Doldan P & Boulant S (2020) Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces, Frontiers in immunology. 11, 608645. - PMC - PubMed
    1. Walter MR (2020) The Role of Structure in the Biology of Interferon Signaling, Frontiers in immunology. 11, 606489. - PMC - PubMed

LinkOut - more resources