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. 2025 Mar 1;15(1):139-141.
doi: 10.4103/mgr.MEDGASRES-D-24-00022. Epub 2024 Jun 26.

New approach of modern pharmacology: from gasotransmitters to traditional mineral drugs

Yefan Duan  1 , Jianfei Sun
Affiliations

New approach of modern pharmacology: from gasotransmitters to traditional mineral drugs

Yefan Duan et al. Med Gas Res. .
No abstract available

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Figures

Figure 1
Figure 1
Anti-inflammation mechanisms of gasotransmitters (H2S and H2). H2S can be produced by CSE, inhibiting the expression of NF-κB, VEGF and SOCS3 and enhancing PPARδ to reduce inflammation and oxidative stress. H2 achieves this effect by inhibiting IL-1β, IL-6, TNF-α, HMGB-1, NF-κB and prostaglandin E2. Created with Adobe Illustrator CS6 (64 Bit). CSE: Cystathionine γ lyase; H2: hydrogen; H2S: hydrogen sulfide; HMGB-1: high mobility group box-1; IL-1β: interleukin-1β; IL-6: interleukin-6; NF-κB: nuclear factor κB; PPARδ: peroxisome proliferator-activated receptor-delta; SOCS3: suppressor of cytokine signaling-3; TNF-α: tumor necrosis factor α; VEGF: vascular endothelial growth factor.
See this image and copyright information in PMC

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