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. 2025 Feb;53(2):406-419.
doi: 10.1007/s10439-024-03633-7. Epub 2024 Oct 22.

An In vivo Pilot Study to Estimate the Swelling of the Aneurysm Wall Rabbit Model Generated with Pulsed Fluid Against the Aneurysm Wall

Guillaume Plet  1 , Jolan Raviol  1 , Jean-Baptiste Langlois  2 , Salim Si-Mohamed  3   4 , Hélène Magoariec  1 , Cyril Pailler-Mattei  5   6
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An In vivo Pilot Study to Estimate the Swelling of the Aneurysm Wall Rabbit Model Generated with Pulsed Fluid Against the Aneurysm Wall

Guillaume Plet et al. Ann Biomed Eng. 2025 Feb.

Erratum in

Abstract

Purpose: This study addresses the critical issue of evaluating the risk of rupture of unruptured intracranial aneurysms (UIAs) through the assessment of the mechanical properties of the aneurysm wall. To achieve this, an original approach based on the development of an in vivo deformation device prototype (DDP) of the vascular wall is proposed. The DDP operates by pulsing a physiological fluid onto the vascular wall and measuring the resulting deformation using spectral photon counting computed tomography (SPCCT) imaging.

Methods: In this preliminary study conducted on a rabbit animal model, an aneurysm was induced on the carotid artery, followed by deformation of the aneurysm sac wall using the DDP. The change in luminal volume of the aneurysm sac induced by the deformation of the vascular wall was then quantified.

Results: The initial experimental results demonstrated an increase in the luminal volume of the aneurysm sac in relation to the increased flow rate of the fluid pulsed by the DDP onto the arterial wall. Measurement of the pressure generated by the DDP in relation to the different flow rate values imposed by the pulsation system revealed experimental values of the same order of magnitude as dynamic blood pressure. Furthermore, theoretical pressure values on the deformed area, calculated using Euler's theorem, appeared to be correlated with experimental pressure measurements.

Conclusion: This equivalence between theory and experiment is a key element in the use of the DDP for estimating the mechanical properties of the vascular wall, particularly for the use of finite element models to characterise the stress state of the deformed vascular wall. This preliminary work thus presents a novel, innovative, and promising approach for the evaluation and management of the risk of rupture of unruptured intracranial aneurysms.

Keywords: Aneurysm animal model; In vivo deformation of aneurysm wall; Pressure against aneurysm wall; Spectral photon computed counting tomography.

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Conflict of interest statement

Declarations. Conflict of interest: The author(s) declared no potential Conflict of interest with respect to the research, authorship, and/or publication of this article. Ethical Approval: All procedures were conducted in accordance with the European Directive 2010/63/UE, approved by the Ethics Committee and authorised by the French Ministry of Higher Education, Research and Innovation (APAFIS#36854).

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