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Randomized Controlled Trial
. 2025 Jun 17;110(7):1811-1817.
doi: 10.1210/clinem/dgae670.

Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes

Barbara A Gower  1 , Amy M Goss  1 , Marian L Yurchishin  1 , Sarah E Deemer  1 , Bhuvana Sunil  2 , William T Garvey  1
Affiliations
Randomized Controlled Trial

Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes

Barbara A Gower et al. J Clin Endocrinol Metab. .

Abstract

Context: β-Cell response to glucose is compromised in individuals with type 2 diabetes (T2D), possibly due in part to excessive carbohydrate consumption.

Objective: This study was conducted to determine if a eucaloric carbohydrate-restricted (CR) diet (∼9% energy from carbohydrate, 65% energy from fat), compared to a eucaloric higher carbohydrate (HC) diet (∼55% energy from carbohydrate, 20% energy from fat), would improve β-cell response to glucose in participants with T2D.

Methods: Participants were 57 African American and European American adults with T2D not using insulin. Medications were discontinued 1 to 2 weeks prior to baseline testing. A hyperglycemic clamp was used to assess the acute (first-phase) and maximal (arginine-stimulated) C-peptide response to glucose at baseline and after 12 weeks of controlled diet therapy (all food provided). An oral glucose tolerance test (OGTT) was used to assess the disposition index (DI).

Results: At 12 weeks, a statistically significant effect of diet was observed on acute C-peptide response (2-fold greater with the CR diet; P < .01). For maximal C-peptide, a significant effect of diet was observed (22% greater with the CR diet; P < .05), as was a significant diet-by-race interaction (P < .05), indicating that the diet effect was specific to European Americans (48% greater with the CR diet; P < .01). OGTT results showed a significant effect of diet on DI at 12 weeks (32% greater with the CR diet; P < .05).

Conclusion: These results suggest that a eucaloric CR diet has beneficial effects on β-cell function in patients with mild T2D.

Keywords: diet therapy; type 2 diabetes; β-cell function.

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References

    1. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840‐846. - PubMed
    1. Abdul-Ghani MA, Tripathy D, DeFronzo R. Contribution of B-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care. 2006;29(5):1130‐1139. - PubMed
    1. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787‐794. - PMC - PubMed
    1. Del Prato S, Marchetti P, Bonadonna RC. Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes. 2002;51(Suppl 1):S109‐S116. - PubMed
    1. Mudaliar S. Choice of early treatment regimen and impact on beta-cell preservation in type 2 diabetes. Int J Clin Pract. 2013;67(9):876‐887. - PubMed

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