The HCT Unit
- PMID: 39437062
- Bookshelf ID: NBK608241
- DOI: 10.1007/978-3-031-44080-9_4
The HCT Unit
Excerpt
Hematopoietic cell transplantation (HCT) is an advanced therapeutic intervention that is required for a number of malignant and nonmalignant medical conditions, often for critically ill patients. The establishment of an HCT program requires the efforts of experienced and appropriately trained personnel to lead the program. Clearly, this also requires financial, legal, ethical, and other institutional support. Without the commitment of the hospital director, allocation of resources, support of the national health authorities, and politicians, an HCT program will not be successful. For newly starting programs, it would be essential to identify minimal requirements for establishing an HCT unit in order to optimize resource utilization as well as maintain safe patient care. While these minimal requirements also apply to well-established units, its structure helps to understand and implement additional steps for larger units which plan to offer additional transplant services and have access to more resources. The recent advent of more cellular therapy types, including immune effector cell therapy, has added another layer of complexity necessitating additional requirements by HCT programs to ensure patient safety.
Copyright 2024, The Author(s).
Sections
- 4.1. Introduction
- 4.2. Inpatient Unit
- 4.3. Ancillary Medical Services
- 4.4. Outpatient Unit
- 4.5. Blood Bank
- 4.6. Laboratory
- 4.7. HLA Typing Lab
- 4.8. Stem Cell Collection
- 4.9. Stem Cell Processing Facility
- 4.10. Radiology
- 4.11. Pharmacy
- 4.12. Staffing and Human Resources
- 4.13. Chimeric Antigen Receptor T-Cell (CAR-T Cell) Unit
- 4.14. Institutional Database and Data Manager
- 4.15. Quality Control
- 4.16. Transplant Coordinator
- Further Reading
References
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- Aljurf M, Weisdorf D, Hashmi SK, Nassar A, Gluckman E, et al. Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources (Part II): Clinical, technical and socio-economic considerations. Hematol Oncol Stem Cell Ther. 2020;13:7–16. - PubMed
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- Booth GS, Gehrie EA, Bolan CD, Savani BN. Clinical guide to ABO-incompatible allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:1152–8. - PubMed
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- Chang CC, Ananda-Rajah M, Belcastro A, et al. Consensus guidelines for implementation of quality processes to prevent invasive fungal disease and enhanced surveillance measures during hospital building works. Intern Med J. 2014;44:1389–97. - PubMed
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- Crysandt M, Yakoub-Agha I, Reiß P, et al. How to build an allogeneic hematopoietic cell transplant unit in 2016: proposal for a practical framework. Curr Res Transl Med. 2017;65:149–54. - PubMed
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