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Review

Autoimmune Disease

Tobias Alexander  1 , Basil Sharrack  2 , Montserrat Rovira  3   4   5 , Riccardo Saccardi  6 , Dominique Farge  7   8 , John A. Snowden  9 , Raffaella Greco  10
Anna Sureda  1 , Selim Corbacioglu  2 , Raffaella Greco  3 , Nicolaus Kröger  4 , Enric Carreras  5
, editors.
In: The EBMT Handbook: Hematopoietic Cell Transplantation and Cellular Therapies [Internet]. 8th edition. Cham (CH): Springer; 2024. Chapter 92.
.
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Review

Autoimmune Disease

Tobias Alexander et al.
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Excerpt

Autoimmune diseases (ADs) are a heterogeneous group of diseases affecting 8–10% of the Western population, which constitute a heavy burden to society and are often debilitating and disabling for affected individuals. ADs are defined as an impairment of the immune system resulting in the loss of immune tolerance against self-tissues, by the existence of autoreactive T and B cells and by a complex mechanism of multifactorial aetiology, across genetics and environmental factors (Alexander and Greco 2022). Autoimmunity is also linked to autoinflammation, having common features as the activation against self, with subsequent systemic inflammation (Chap. 93).

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References

    1. Achini‐Gutzwiller FR, Snowden JA, Corbacioglu S, Greco R. Haematopoietic stem cell transplantation for severe autoimmune diseases in children: a review of current literature, registry activity and future directions on behalf of the autoimmune diseases and paediatric diseases working parties of the European Society for Blood and Marrow Transplantation. Br J Haematol. 2022;198:24–45. https://doi.org/10.1111/bjh.18176. - DOI - PubMed
    1. Alchi B, Jayne D, Labopin M, Demin A, Sergeevicheva V, Alexander T, Gualandi F, Gruhn B, Ouyang J, Rzepecki P, et al. Autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: data from the European Group for Blood and Marrow Transplantation registry. Lupus. 2013;22:245–53. https://doi.org/10.1177/0961203312470729. - DOI - PubMed
    1. Alexander T, Greco R. Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases: overview and future considerations from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 2022;57:1055–62. https://doi.org/10.1038/s41409-022-01702-w. - DOI - PMC - PubMed
    1. Alexander T, Thiel A, Rosen O, Massenkeil G, Sattler A, Kohler S, Mei H, Radtke H, Gromnica-Ihle E, Burmester GR, et al. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood. 2009;113:214–23. https://doi.org/10.1182/blood-2008-07-168286. - DOI - PubMed
    1. Alexander T, Sattler A, Templin L, Kohler S, Gross C, Meisel A, Sawitzki B, Burmester GR, Arnold R, Radbruch A, et al. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann Rheum Dis. 2013;72:1549–58. https://doi.org/10.1136/annrheumdis-2012-202216. - DOI - PubMed

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