Feasibility and Experiences of HCT in Resource-Constrained Settings
- PMID: 39437086
- Bookshelf ID: NBK608295
- DOI: 10.1007/978-3-031-44080-9_69
Feasibility and Experiences of HCT in Resource-Constrained Settings
Excerpt
Even though hematopoietic cell transplant (HCT) has been in vogue for more than six decades as a curative therapy for many hematological disorders, with increasing trends in all parts of the world (Fig. 69.1), the density of HCT services is low and access to existing services remain an unmet need in the resource-constrained settings (RCSs) of low- and middle-income countries (LMICs) (Niederwieser et al. 2022). The silver lining though is that within these limitations, there are several examples of high-quality HCT services functioning in several countries, some with full national/international accreditation showing that even in those circumstances this is possible (Damodar et al. 2021). The goal of this chapter will be to discuss how good HCT services may be established and sustained in RCSs (Pasquini et al. 2019; Faulkner et al. 2021).
Copyright 2024, The Author(s).
Sections
- 69.1. Introduction
- 69.2. Establishing HCT Centers: Personnel/Infrastructure/Types of HCTs
- 69.3. Patient Selection and Indications for HCT
- 69.4. Donor Selection: Alternative Donors—Graft Manipulations
- 69.5. Harvest of Graft: CD34+ HSC Dose Calculation and Cryopreservation Issues
- 69.6. Conditioning Regimen
- 69.7. Supportive Care
- 69.8. Graft Versus Host Disease (GVHD) Management
- 69.9. Long-term Follow-Up
- 69.10. Socioeconomic Issues
- 69.11. Conclusion
- References
References
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