Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Conditioning

Avichai Shimoni  1 , Vera Radici  2 , Arnon Nagler  1
Anna Sureda  1 , Selim Corbacioglu  2 , Raffaella Greco  3 , Nicolaus Kröger  4 , Enric Carreras  5
, editors.
In: The EBMT Handbook: Hematopoietic Cell Transplantation and Cellular Therapies [Internet]. 8th edition. Cham (CH): Springer; 2024. Chapter 13.
.
Affiliations
Free Books & Documents
Review

Conditioning

Avichai Shimoni et al.
Free Books & Documents

Excerpt

Hematopoietic cell transplantation (HCT) is a potentially curative therapeutic procedure in a broad range of malignant and nonmalignant hematological disorders. Conditioning is the preparative regimen that is administered to patients undergoing HCT before the infusion of stem cell (SC) grafts. The selection of an optimal conditioning regimen is critical for transplantation success.

PubMed Disclaimer

References

    1. Aoudjhane M, Labopin M, Gorin NC, et al. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the acute leukemia working party (ALWP) of the European Group for Blood and Marrow Transplantation (EBMT). Leukemia. 2005;19:2304–12. - PubMed
    1. Bacigalupo A, Ballen K, Rizzo D, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant. 2009;15:1628–33. - PMC - PubMed
    1. Battipaglia G, Mauff K, Wendel L, et al. Thiotepa-busulfan-fludarabine (TBF) conditioning regimen in patients undergoing allogeneic hematopoietic cell transplantation for myelofibrosis: an outcome analysis from the chronic malignancies working party of the EBMT. Bone Marrow Transplant. 2021;56:1593–602. - PubMed
    1. Beelen DW, Trenschel R, Stelljes M, et al. Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial. Lancet Haematol. 2020;7:e28–39. - PubMed
    1. Blaise D, Tabrizi R, Boher JM, et al. Randomized study of 2 reduced-intensity conditioning strategies for human leukocyte antigen-matched, related allogeneic peripheral blood stem cell transplantation: prospective clinical and socioeconomic evaluation. Cancer. 2013;119:602–11. - PubMed

LinkOut - more resources