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Review

Iron Overload

Emanuele Angelucci  1 , Anna Maria Raiola  1
Anna Sureda  1 , Selim Corbacioglu  2 , Raffaella Greco  3 , Nicolaus Kröger  4 , Enric Carreras  5
, editors.
In: The EBMT Handbook: Hematopoietic Cell Transplantation and Cellular Therapies [Internet]. 8th edition. Cham (CH): Springer; 2024. Chapter 46.
.
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Review

Iron Overload

Emanuele Angelucci et al.
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Excerpt

Iron overload/toxicity is an unavoidable consequence in several diseases characterized by anemia and red blood cell transfusion requirement. Iron toxicity can impact on transplant outcome by increasing oxidative stress. Impact of iron toxicity is different in the different stages of HCT.

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References

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    1. Angelucci E. Hematopoietic stem cell transplantation in thalassemia. Hematology Am Soc Hematol Educ Program. 2010b;2010:456–62. - PubMed
    1. Angelucci E, Pilo F. Management of iron overload before, during, and after hematopoietic stem cell transplantation for thalassemia major. Ann N Y Acad Sci. 2016;1368:115–21. - PubMed
    1. Angelucci E, Muretto P, Lucarelli G, et al. Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation. Italian cooperative group for phlebotomy treatment of transplanted thalassemia patients. Blood. 1997a;90:994–8. - PubMed
    1. Angelucci E, Muretto P, Lucarelli G, et al. Treatment of iron overload in the “ex-thalassemic”. Report from the phlebotomy program. Ann N Y Acad Sci. 1998;850:288–93. - PubMed

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