Structural racism and inequity in cancer clinical trial participation: time for solutions

Abhijit Pal^{1

2

3

4

5}, Rayan Saleh Moussa⁶, Ben Smith⁷, Bernadette Brady^{4

8}, Deme Karikios^{2

9}, Frances Boyle², Wei Chua^{1

3

4}

Affiliations

¹ Department of Medical Oncology, Liverpool Hospital, Sydney, NSW, Australia.
² University of Sydney, NSW, Australia.
³ Western Sydney University, Sydney, NSW, Australia.
⁴ Australian centre for Cancer Equity, A Joint Venture between South Western Sydney Local Health District and Ingham Institute for Applied Medical Research, Sydney, Australia.
⁵ Department of Medical Oncology, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia.
⁶ Research Institute for Innovative Solutions for Wellbeing and Health, Improving Palliative, Aged and Chronic Care through Clinical Research and Translation, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
⁷ The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council NSW, Sydney, NSW, Australia.
⁸ Department of Physiotherapy, Liverpool Hospital, Sydney, NSW, Australia.
⁹ Department of Medical Oncology, Nepean Hospital, Sydney, NSW, Australia.

PMID: 39438028
PMCID: PMC11495864
DOI: 10.1093/jncics/pkae089

Editorial

Structural racism and inequity in cancer clinical trial participation: time for solutions

Abhijit Pal et al. JNCI Cancer Spectr. 2024.

. 2024 Sep 2;8(5):pkae089.

doi: 10.1093/jncics/pkae089.

Authors

Abhijit Pal^{1

2

3

4

5}, Rayan Saleh Moussa⁶, Ben Smith⁷, Bernadette Brady^{4

8}, Deme Karikios^{2

9}, Frances Boyle², Wei Chua^{1

3

4}

Affiliations

¹ Department of Medical Oncology, Liverpool Hospital, Sydney, NSW, Australia.
² University of Sydney, NSW, Australia.
³ Western Sydney University, Sydney, NSW, Australia.
⁴ Australian centre for Cancer Equity, A Joint Venture between South Western Sydney Local Health District and Ingham Institute for Applied Medical Research, Sydney, Australia.
⁵ Department of Medical Oncology, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia.
⁶ Research Institute for Innovative Solutions for Wellbeing and Health, Improving Palliative, Aged and Chronic Care through Clinical Research and Translation, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
⁷ The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council NSW, Sydney, NSW, Australia.
⁸ Department of Physiotherapy, Liverpool Hospital, Sydney, NSW, Australia.
⁹ Department of Medical Oncology, Nepean Hospital, Sydney, NSW, Australia.

PMID: 39438028
PMCID: PMC11495864
DOI: 10.1093/jncics/pkae089

No abstract available

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Conflict of interest statement

A.P. has received consulting fees from Novotech; educational expenses from AstraZeneca, Cipla, and Janssen; conference support from Pfizer; and travel support from Merck Sharp & Dohme. F.B. has received fees for advisory boards for Roche, Novartis, Eisai, Pfizer, and Eli Lilly. Friends of the Mater Foundation support her academic appointment at the University of Sydney. R.M., B.S., B.B., D.K., and W.C. have no conflicts to declare.

Comment in

Re: Structural racism and inequity in cancer clinical trial participation: time for solutions.
Underhill C, Sabesan S, Green M. Underhill C, et al. JNCI Cancer Spectr. 2025 Mar 3;9(2):pkaf013. doi: 10.1093/jncics/pkaf013. JNCI Cancer Spectr. 2025. PMID: 40257430 Free PMC article. No abstract available.

Comment on

Mediators of racial and ethnic inequities in clinical trial participation among patients with cancer, 2011-2023.
Guadamuz JS, Wang X, Altomare I, Camelo Castillo W, Sarkar S, Mamtani R, Calip GS. Guadamuz JS, et al. JNCI Cancer Spectr. 2024 Sep 2;8(5):pkae085. doi: 10.1093/jncics/pkae085. JNCI Cancer Spectr. 2024. PMID: 39271476 Free PMC article.

References

1. Guadamuz JS, Wang X, Altomare I, et al. Mediators of racial and ethnic inequities in clinical trial participation among patients with cancer, 2011-2023. JNCI Cancer Spectr. 2024. doi: 10.1093/jncics/pkae085. - DOI - PMC - PubMed
1. Freedman L. Inclusion of women and minorities in clinical trials and the NIH Revitalization Act 1993 - the perspective of NIH trial lists. Controlled Clinical Trials,. 1995;16(5):277. - PubMed
1. Smith AB, Agar M, Delaney G, et al. Lower trial participation by culturally and linguistically diverse (CALD) cancer patients is largely due to language barriers. Asia-Pac J Clin Oncol. 2018;14(1):52-60. - PubMed
1. Guadamuz JS, Wang X, Ryals CA, et al. Socioeconomic status and inequities in treatment initiation and survival among patients with cancer, 2011-2022. JNCI Cancer Spectr. 2023;7(5):pkad058. - PMC - PubMed
1. AACR Cancer Disparities Progress Report 2024. Philadelphia: American Association for Cancer Research; 2024. https://cancerdisparitiesprogressreport.org. Accessed September 9, 2024.

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Structural racism and inequity in cancer clinical trial participation: time for solutions

Affiliations

Structural racism and inequity in cancer clinical trial participation: time for solutions

Authors

Affiliations

Conflict of interest statement

Comment in

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References

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