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Randomized Controlled Trial
. 2024;14(5):173-187.
doi: 10.1080/17582024.2024.2404385. Epub 2024 Oct 22.

Benefits of self-paced concurrent training on lung function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis

Sonda Jallouli  1   2 , Rami Maaloul  2   3 , Sameh Ghroubi  1 , Rim Kammoun  4 , Mariem Damak  5   6 , Salma Sakka  5   6 , Tarak Driss  7 , Giovanni de Marco  7 , Chokri Mhiri  5   6 , Mohamed Habib Elleuch  1 , Walid Feki  8 , Omar Hammouda  3   7
Affiliations
Randomized Controlled Trial

Benefits of self-paced concurrent training on lung function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis

Sonda Jallouli et al. Neurodegener Dis Manag. 2024.

Abstract

Aim: Studying the effects of self-paced concurrent high-intensity interval training and resistance training (HIIT-RT) on respiratory function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis (PwMS).Methods: Twenty-three PwMS were randomized into a 12-week training group (three times per week) (TG, n = 11) or a control group (CG, n = 12). Lung function (spirometry), aerobic capacity (graded cardiopulmonary-exercise-testing) and perceived fatigue (Fatigue Severity Scale (FSS)) were evaluated pre- and post-intervention.Results: The forced vital capacity (p = 0.036, Hedges'g (g) = 0.93), forced expiratory time (p = 0.045, g = 0.88), peak expiratory flow (p = 0.043, g = 0.89) increased in TG compared with CG. The TG showed an increase in peak aerobic power (p = 0.004, g = 1.34) and peak oxygen uptake (p < 0.001, g = 2.58) compared with CG. There was a decrease in ventilatory equivalent for carbon dioxide (p = 0.02, g = 1.02) and FSS scores (p < 0.001, g = 1.72) in TG comparatively with CG.Conclusion: 12-week self-paced HIIT-RT enhanced lung function as well as aerobic fitness, and alleviated fatigue perception in PwMS.

Keywords: concurrent training; fitness testing; metabolic responses; perceived fatigue; relapsing-remitting multiple sclerosis; spirometry.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Figures

None
Graphical abstract
Figure 1.
Figure 1.
Experimental protocol. Note: ETO2: End-tidal oxygen pressure; ETCO2: End-tidal carbon dioxide pressure; FET: Forced expiratory time; FVC: Forced vital capacity; FEV1: Forced expiratory volume in the first second, FIF50%: Forced inspiratory flow at 50% FVC; FEF50%: Forced expiratory flow at 50% FVC; FEF25–75%: Forced expiratory flow at 25–75% of FVC; HRpeak: Peak heart rate; lactatepeak: Peak lactate level; PAP: Peak aerobic power; PEF: Peak expiratory flow; RPE: Rating of perceived exertion; RM: One-repetition maximum; T0: Pre-test; T1: Post-test; VO2peak: Peak oxygen uptake; VeqO2: Ventilatory equivalent for oxygen; VeqCO2: Ventilatory equivalent for carbon dioxide; VEpeak: Peak pulmonary ventilation.
Figure 2.
Figure 2.
CONSORT flow diagram illustrating the recruitment, randomization and follow-up of participants during the study.
See this image and copyright information in PMC

References

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    2. • This cross-sectional study revealed that poor cardiopulmonary fitness (VO2peak) was a predictor factor of perceived fatigue (R2 = 13%) in patients with multiple sclerosis (PwMS), thus highlighting the importance of investigating these parameters in the same study, and providing a means to discuss fatigue alleviation.

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