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. 2024 Sep 23;21(13):2494-2501.
doi: 10.7150/ijms.101020. eCollection 2024.

Genetic associations of visfatin polymorphisms with clinicopathologic characteristics of prostate cancer in Taiwanese males

Sung-Lin Hu  1   2 , Shan-Chi Liu  3 , Chia-Yen Lin  4   5   6 , Yi-Chin Fong  7   8   9 , Shian-Shiang Wang  4   5   10 , Li-Chai Chen  11 , Shun-Fa Yang  12   13 , Chih-Hsin Tang  14   15   16   17
Affiliations

Genetic associations of visfatin polymorphisms with clinicopathologic characteristics of prostate cancer in Taiwanese males

Sung-Lin Hu et al. Int J Med Sci. .

Abstract

The most general cancer in men is prostate cancer (PCa), with its risk increasing due to age and obesity. Visfatin, a member of adipokines, is related to cancer progression and metastasis, but its relationship in PCa remains undetermined. In addition, no knowledge is available regarding relations between visfatin polymorphisms and clinicopathological characteristics in PCa. We sought to investigate the functions of four visfatin gene polymorphisms and clinicopathological characteristics on the hazard of developing PCa in 695 Taiwanese males with PCa. Carriers of the GA+AA heterozygote of SNP rs61330082 were at a markedly higher risk of biochemical recurrence than those with the GG genotype. Visfatin rs61330082 and rs11977021 were related with a high risk of perineural invasion, lymphovascular invasion, and biochemical recurrence in prostate-specific antigen (PSA) > 10 PCa patients. The Cancer Genome Atlas database noted that visfatin mRNA level did not prominently differ with pathological T/N stage and overall survival. This finding is the first to document a connection between visfatin polymorphisms and clinicopathological characteristics of PCa in Taiwanese males.

Keywords: Prostate cancer; Single nucleotide polymorphism; Taiwanese males; Visfatin.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The visfatin mRNA level of PCa patients from TCGA database. Levels of visfatin mRNA expression in whole population (A&B) and PSA < 10 group (C&D) PCa patients retrieved from TCGA dataset records.
Figure 2
Figure 2
The visfatin mRNA level and overall survival of PCa from the TCGA database. Kaplan-Meier analysis examined levels of visfatin expression and overall survival rates of whole population (A&B) and PSA < 10 group (C&D) PCa patients.
See this image and copyright information in PMC

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