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Review
. 2024 Nov;41(11):e15934.
doi: 10.1111/echo.15934.

Evidence-Based Data on the Diagnostic Role and Clinical Usefulness of [18F]FDG PET/CT in Endocarditis and Cardiac Device Infections

Elena Caporali  1   2 , Gaetano Paone  3   4 , Giorgio Moschovitis  1 , Maria Luisa De Perna  1 , Elia Lo Priore  5 , Enos Bernasconi  4   5 , Giovanni Pedrazzini  1   4 , Giorgio Treglia  3   4   6
Affiliations
Review

Evidence-Based Data on the Diagnostic Role and Clinical Usefulness of [18F]FDG PET/CT in Endocarditis and Cardiac Device Infections

Elena Caporali et al. Echocardiography. 2024 Nov.

Abstract

Infective endocarditis and infection of cardiac devices are conditions characterized by high morbidity and mortality, thus requiring a prompt diagnosis. Advanced imaging modalities are often required in the management of infectious endocarditis according to guidelines. The aim of this review is to collect and describe evidence-based knowledge about the diagnostic role and clinical usefulness of [18F]FDG PET/CT in endocarditis and cardiac device infections based on published systematic reviews and meta-analyses on this topic and on recent guidelines. [18F]FDG PET/CT is recommended only in selected cases. This imaging method has good diagnostic accuracy in detecting prosthetic valve endocarditis and cardiac device infection. Furthermore, it can identify extra-cardiac infectious foci changing the clinical management in a significant percentage of cases.

Keywords: FDG; PET; advanced imaging; cardiac device; endocarditis; hybrid imaging; infection.

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References

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    1. P. Vinod, M. Khayata, A. Haouzi, et al., “Role of Multimodality Imaging in Infective Endocarditis: A Comparison of the Major Society Guidelines in the United States and Europe”, Trends in Cardiovascular Medicine (2024): 00035‐5.
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    1. G. Treglia, “Diagnostic Performance of 18F‐FDG PET/CT in Infectious and Inflammatory Diseases According to Published Meta‐Analyses”, Contrast Media & Molecular Imaging 2019 (2019): 3018349.
    1. S. Hess, E. Noriega‐Álvarez, L. Leccisotti, et al., “EANM Consensus Document on the Use of [18F]FDG PET/CT in Fever and Inflammation of Unknown Origin”, European Journal of Nuclear Medicine and Molecular Imaging 51, no. 9 (2024): 2597–2613.

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