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Editorial
. 2024 Nov;44(11):2288-2290.
doi: 10.1161/ATVBAHA.124.321812. Epub 2024 Oct 23.

Rap1 Brings the A Game to Control Lung Endothelium

Miguel Martín-Aragón Baudel  1 , Madeline Nieves-Cintrón  1 , Manuel F Navedo  1
Affiliations
Editorial

Rap1 Brings the A Game to Control Lung Endothelium

Miguel Martín-Aragón Baudel et al. Arterioscler Thromb Vasc Biol. 2024 Nov.
No abstract available

Keywords: Editorials; arteriosclerosis; inflammation; lung; thrombosis.

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Conflict of interest statement

None.

Figures

Figure:
Figure:. Cartoon of the proposed mechanism by which Rap1A selectively modulates Orai1 functional expression to control store-operated Ca2+ entry (SOCE), NFAT activation, endothelial inflammation, and permeability.
The gray arrow reflects the control condition. The black arrows indicate increased functional expression of the Orai1 channel, resulting in heightened activation of the NFAT pathway and the induction of a proinflammatory gene profile, which promotes EC inflammation and permeability following the loss/reduction of Rap1A expression. ?? indicates unclear mechanism of action and potential areas for future research. Calcineurin: CaN, endothelial cells: EC, phosphorylated NFAT: pNFAT. Figure generated in Biorender.com.
See this image and copyright information in PMC

Comment on

References

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