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Review
. 2024 Dec;45(4):943-951.
doi: 10.1016/j.ccm.2024.08.014. Epub 2024 Sep 20.

Future Directions in Therapies for Acute Respiratory Distress Syndrome

Jonathan E Millar  1 , Kiran Reddy  2 , Lieuwe D J Bos  3
Affiliations
Review

Future Directions in Therapies for Acute Respiratory Distress Syndrome

Jonathan E Millar et al. Clin Chest Med. 2024 Dec.

Abstract

Acute respiratory distress syndrome (ARDS) is caused by a complex interplay among hyperinflammation, endothelial dysfunction, and alveolar epithelial injury. Targeted treatments toward the underlying pathways have been unsuccessful in unselected patient populations. The first reliable biological subphenotypes reflective of these biological disease states have been identified in the past decade. Subphenotype targeted intervention studies are needed to advance the pharmacologic treatment of ARDS.

Keywords: ARDS; Inflammation; Phenotype; Treatment.

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Conflict of interest statement

Disclosure L. D.J. Bos reports funding from Health Holland, Longfonds, ZonMw, Innovative Medicine Initiative and has consulted for Astra Zeneca, Pfizer, Sobi, Novartis, CSL Behring, Scailyte, and Santhera. All financial contributions were paid to the institution. J.E. Millar and K. Reddy declare no COI.

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