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. 2025 Jan;79(1):196-203.
doi: 10.1007/s11418-024-01851-w. Epub 2024 Oct 23.

Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity

Rena Takizawa #  1 , Tomoyo Minamizono #  1 , Daisuke Tsuji  2 , Xiao-Jie Yan  3 , Feng-Lai Lu  3 , Xue-Rong Yang  3 , Dian-Peng Li  4 , Reiko Akagi  2 , Yoshiki Kashiwada  1 , Naonobu Tanaka  5
Affiliations

Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity

Rena Takizawa et al. J Nat Med. 2025 Jan.

Abstract

Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in Guangxi Zhuang Autonomous Region, China, resulted in the isolation of 13 secondary metabolites including two methoxyflavones, six flavonoid glycosides, and five caffeoyl phenylethanoid glycosides. Among these, the chemical structures of previously undescribed metabolites (1-3) were elucidated to be nevadensin 7-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (1), nevadensin 7-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (2), and 2-(3,4-dihydroxyphenyl)ethyl-1-O-β-D-apiofuranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 3)-β-D-(6'-O-E-caffeoyl)glucopyranoside (3) by detailed spectroscopic and HPLC analyses. Inhibitory activity of isolated compounds against RSL3-induced ferroptosis on human hepatoma Hep3B cells were evaluated.

Keywords: Lysionotus pauciflorus; Anti-ferroptosis activity; Caffeoyl phenylethanoid glycoside; Methoxyflavone glucoside.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article.

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