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Review
. 2024 Sep 27;10(19):e38660.
doi: 10.1016/j.heliyon.2024.e38660. eCollection 2024 Oct 15.

The role of m5C RNA modification in cancer development and therapy

Li Yu  1 , Hongen Xu  2   3 , Hanchu Xiong  3 , Chunju Yang  1 , Ying Wu  1 , Qiong Zhang  1
Affiliations
Review

The role of m5C RNA modification in cancer development and therapy

Li Yu et al. Heliyon. .

Abstract

RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been reported to participate in tumorigenesis and tumor progression. The role of m6A in carcinogenesis has been well studied and summarized. In this review, we described the biological functions of m5C RNA modifications in tumorigenesis and tumor progression. Moreover, we highlighted the molecular mechanisms of m5C RNA modification in oncogenesis. Furthermore, we discussed whether targeting m5C regulator-associated genes could be a novel strategy for improving therapeutic outcomes in patients with cancer.

Keywords: Cancer; Prognosis; RNA; Treatment; m5C.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
The role of NSUN2 in tumorigenesis.
Fig. 2
Fig. 2
The role of NSUN3, NSUN5, NSUN6 and ALYREF in tumorigenesis.
See this image and copyright information in PMC

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