Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Oct 8:12:1423786.
doi: 10.3389/fped.2024.1423786. eCollection 2024.

Case Report: Fetomaternal hemorrhage and its association with pronounced neonatal anemia

Peng Li  1 , Hua Shu  1   2 , Peng Lin  1   2 , Jishui Wang  1   2 , Di Zhang  1   2 , Dongmei Man  1   2 , Fengge Wang  1   2
Affiliations
Case Reports

Case Report: Fetomaternal hemorrhage and its association with pronounced neonatal anemia

Peng Li et al. Front Pediatr. .

Abstract

Fetomaternal hemorrhage (FMH) is a perplexing obstetric condition that predominantly occurs during the third trimester or at the time of delivery. Its insidious and non-specific onset often leads to diagnostic challenges. The underlying pathophysiology of FMH remains incompletely understood, though it is primarily attributed to compromise of the placental barrier. The severity of the condition is intrinsically associated with the volumn of blood loss, the hemorrhage rate, and the presence of alloimmunity. Upon the occurrence of severe FMH, it can rapidly lead to intrauterine distress, fetal anemia, and the possibility of fetal demise, presenting a considerable threat to both maternal and neonatal well-being. In this article, I present a substantial case of FMH and conduct a systematic review of the current scientific literature regarding the etiology, clinical manifestations, diagnostic approaches, treatment highlights, and prognosis of this condition. The objective of this work is to improve clinicians' comprehension and diagnostic proficiency concerning FMH.

Keywords: case report; fetomaternal hemorrhage; obstetrics; pregnancy; severe neonatal anemia.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
CTG monitoring conducted upon admission.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Piva I, Iannone P, Morano D, Greco P. Untimely diagnosis of fetomaternal hemorrhage: what went wrong? J Perinat Med. (2018) 47(1):61–7. 10.1515/jpm-2017-0344 - DOI - PubMed
    1. Bianchi DW, Romero R. Biological implications of bi-directional fetomaternal cell traffic: a summary of a national institute of child health and human development-sponsored conference. J Matern Fetal Neonatal Med. (2003) 14(2):123–9. 10.1080/jmf.14.2.123.129 - DOI - PubMed
    1. Stefanovic V. Fetomaternal hemorrhage complicated pregnancy: risks, identification, and management. Curr Opin Obstet Gynecol. (2016) 28(2):86–94. 10.1097/GCO.0000000000000248 - DOI - PubMed
    1. Schmit M, Duminil L, Loron G, Bednarek N, Graesslin O, Raimond E. Massive feto-maternal hemorrhage: two cases. J Gynecol Obstet Hum Reprod. (2019) 48(7):533–5. 10.1016/j.jogoh.2019.03.012 - DOI - PubMed
    1. Sueters M, Arabin B, Oepkes D. Doppler Sonography for predicting fetal anemia caused by massive fetomaternal hemorrhage. Ultrasound Obstet Gynecol. (2003) 22(2):186–9. 10.1002/uog.190 - DOI - PubMed

Publication types

LinkOut - more resources