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Review
. 2024 Oct 31;38(20):e70130.
doi: 10.1096/fj.202402126R.

LC3-associated phagocytosis and human diseases: Insights from mechanisms to therapeutic potential

Xu Chen  1   2 , Qi Su  1 , Ruize Gong  2 , Xing Ling  1 , Runxiao Xu  1 , Qijia Feng  1 , Jialiang Ke  1 , Meng Liu  1 , Gulipiyanmu Kahaerjiang  1 , Yuhang Liu  1 , Yanyan Yang  1 , Zhihong Jiang  2 , Hongmei Wu  1 , Yitao Qi  1
Affiliations
Review

LC3-associated phagocytosis and human diseases: Insights from mechanisms to therapeutic potential

Xu Chen et al. FASEB J. .

Abstract

LC3-associated phagocytosis (LAP) is a distinct type of autophagy that involves the sequestration of extracellular material by phagocytes. Beyond the removal of dead cells and cellular debris from eukaryotic cells, LAP is also involved in the removal of a variety of pathogens, including bacteria, fungi, and viruses. These events are integral to multiple physiological and pathological processes, such as host defense, inflammation, and tissue homeostasis. Dysregulation of LAP has been associated with the pathogenesis of several human diseases, including infectious diseases, autoimmune diseases, and neurodegenerative diseases. Thus, understanding the molecular mechanisms underlying LAP and its involvement in human diseases may provide new insights into the development of novel therapeutic strategies for these conditions. In this review, we summarize and highlight the current consensus on the role of LAP and its biological functions in disease progression to propose new therapeutic strategies. Further studies are needed to illustrate the precise role of LAP in human disease and to determine new therapeutic targets for LAP-associated pathologies.

Keywords: LAP‐associated pathology; LC3‐associated phagocytosis; molecular mechanism; therapeutic strategy.

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References

REFERENCES

    1. Tsukada M, Ohsumi Y. Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae. FEBS Lett. 1993;333:169‐174.
    1. Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. 2019;176:11‐42.
    1. Nie T, Zhu L, Yang Q. The classification and basic processes of autophagy. Adv Exp Med Biol. 2021;1208:3‐16.
    1. Köster S, Upadhyay S, Chandra P, et al. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3‐associated phagocytosis by the LCP protein CpsA. Proc Natl Acad Sci USA. 2017;114:E8711‐E8720.
    1. Chen Y, He Y, Wu X, et al. Rubicon promotes the M2 polarization of Kupffer cells via LC3‐associated phagocytosis‐mediated clearance to improve liver transplantation. Cell Immunol. 2022;378:104556.

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