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Comment
. 2024 Oct 25;386(6720):380-381.
doi: 10.1126/science.adt2538. Epub 2024 Oct 24.

A pro-oxidant suppresses unrelated diseases

Emanuela Pannia  1 , James J Dowling  1   2   3
Affiliations
Comment

A pro-oxidant suppresses unrelated diseases

Emanuela Pannia et al. Science. .

Abstract

A lipid kinase inhibitor ameliorates both prostate cancer and a muscle disease in mice.

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  • Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.
    Swamynathan MM, Kuang S, Watrud KE, Doherty MR, Gineste C, Mathew G, Gong GQ, Cox H, Cheng E, Reiss D, Kendall J, Ghosh D, Reczek CR, Zhao X, Herzka T, Špokaitė S, Dessus AN, Kim ST, Klingbeil O, Liu J, Nowak DG, Alsudani H, Wee TL, Park Y, Minicozzi F, Rivera K, Almeida AS, Chang K, Chakrabarty RP, Wilkinson JE, Gimotty PA, Diermeier SD, Egeblad M, Vakoc CR, Locasale JW, Chandel NS, Janowitz T, Hicks JB, Wigler M, Pappin DJ, Williams RL, Cifani P, Tuveson DA, Laporte J, Trotman LC. Swamynathan MM, et al. Science. 2024 Oct 25;386(6720):eadk9167. doi: 10.1126/science.adk9167. Epub 2024 Oct 25. Science. 2024. PMID: 39446948 Free PMC article.

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