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. 2024 Dec;50(12):108773.
doi: 10.1016/j.ejso.2024.108773. Epub 2024 Oct 18.

Prognostic value of the advanced lung cancer inflammation index in intrahepatic cholangiocarcinoma

Giovanni Catalano  1 , Laura Alaimo  1 , Odysseas P Chatzipanagiotou  2 , Andrea Ruzzenente  3 , Federico Aucejo  4 , Hugo P Marques  5 , Vincent Lam  6 , Tom Hugh  7 , Nazim Bhimani  7 , Shishir K Maithel  8 , Minoru Kitago  9 , Itaru Endo  10 , Guillaume Martel  11 , Carlo Pulitano  12 , Feng Shen  13 , Irinel Popescu  14 , Bas Groot Koerkamp  15 , Todd W Bauer  16 , François Cauchy  17 , George A Poultsides  18 , Matthew Weiss  19 , Ana Gleisner  20 , Timothy M Pawlik  21
Affiliations

Prognostic value of the advanced lung cancer inflammation index in intrahepatic cholangiocarcinoma

Giovanni Catalano et al. Eur J Surg Oncol. 2024 Dec.

Abstract

Introduction: The advanced lung cancer inflammation index (ALI), which combines inflammation and nutrition data, was recently proposed as a prognostic biomarker. We assessed the impact of ALI on overall survival (OS) among patients undergoing surgery for intrahepatic cholangiocarcinoma (ICC).

Methods: Patients who underwent surgery for ICC were identified from an international cohort. ALI was calculated as body-mass index (BMI)∗albumin/neutrophil-to-lymphocyte ratio; patients were categorized into "low-" and "high-ALI" using log-rank statistics. The impact of ALI on OS was compared against other inflammatory markers (i.e., neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], systemic immune inflammation index [SII = platelets∗NLR]) using Harrell's Concordance index (C-index) and the Akaike Information Criterion (AIC). To minimize intergroup differences, propensity score matching was employed.

Results: Among 1045 patients, more than one-half of individuals underwent major hepatectomy (n = 582, 55.7 %), median tumor size was 5.5 cm (IQR, 3.8-7.8), and median ALI was 38.9 (IQR 26.5-57.2). On multivariate analysis, low ALI was an independent risk factor for worse OS (HR 1.21, 95 % CI 1.01-1.46; p = 0.04). Patients with low ALI had worse 5-year OS (36.9 % vs. 49.9 %; p < 0.001), which remained significant after PSM (36.9 % vs. 41.3 %; p = 0.039). ALI had a comparable discriminatory ability compared with NLR, PLR, and SII (C-index: 0.646 vs. 0.644 vs. 0.640 vs. 0.641, respectively), yet had a lower AIC (5475.31 vs. 5546.80 vs. 5550.45 vs. 5548.62, respectively) suggesting slightly better model fit and accuracy.

Conclusions: ALI was an independent predictor of OS among patients undergoing surgery for ICC. Nutritional and inflammatory markers should be incorporated into predictive models to improve prognostic stratification.

Keywords: Cancer surgery; Cholangiocarcinoma; Inflammation; Malnutrition.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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