Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jan;79(1):15-6.
doi: 10.1177/014107688607900105.

Three times daily or 8-hourly

R Nigam, B J Loveday, S L Grainger, D G Maxton

Three times daily or 8-hourly

R Nigam et al. J R Soc Med. 1986 Jan.

Abstract

The timing of drug ingestion over 24 hours was assessed in 58 outpatients taking drugs three times daily. The mean time between 1st and 2nd dose was 5.7 hours, 2nd and 3rd 6.1 hours and between 3rd and 1st of the next day 12.2 hours. Based on a simulation of hydralazine pharmacokinetics, such irregular administration would increase peak levels by 10% and decrease trough levels by 64% compared with regular 8-hourly doses.

PubMed Disclaimer

References

    1. Clin Pharmacokinet. 1977 Sep-Oct;2(5):317-29 - PubMed
    1. Eur J Clin Pharmacol. 1979 Mar 26;15(2):97-103 - PubMed
    1. J R Coll Physicians Lond. 1983 Apr;17(2):126-32 - PubMed
    1. Practitioner. 1982 Mar;226(1365):573-5 - PubMed
    1. Br Med J. 1969 Jan 25;1(5638):218-22 - PubMed

Substances